Kansas University football assistant coach Earle Mosley has resigned for health reasons, and head coach Mark Mangino announced Friday that Louie Matsakis would be Mosley’s replacement.

Mosley, 60, was entering his third year as KU’s running backs coach. He has been in coaching since 1975, with stops at places like Notre Dame, Stanford and the NFL’s Chicago Bears.

“Earle did an outstanding job with our running backs,” Mangino said in a statement. “He surely will be missed. However, we will continue to encourage Earle as he deals with his health issues.”

Matsakis, 29, will coach the running backs and coordinate the special teams at KU. He spent the last year as special-teams coordinator at NCAA Division-III Capital University in Columbus, Ohio. He is the younger brother of George Matsakis, KU’s director of football operations.

Louie Matsakis previously worked at on Mangino’s staff in 2004 and 2005 as director of quality control. In that role, he worked with the special-teams coordinator, worked in an administrative role doing statistical analysis and scouting reports and was involved in on-campus recruiting, camps and clinics.

Matsakis was the special-teams coordinator at Texas State-San Marcos in 2003 and was a special-teams intern at Texas Tech from 2000-02. He was a three-year letterman as a punter and kicker at Emporia State in the 1990s.