Los Angeles ? Martin Scorsese and Leonardo DiCaprio’s voyage to “Shutter Island” has landed them at No. 1 at the weekend box office.

Their creepy crime thriller set at a remote insane asylum opened with $40.2 million, according to studio estimates Sunday. A Paramount Pictures release, “Shutter Island” is the fourth collaboration for Scorsese and DiCaprio and the best opening yet for both the director and star.

Scorsese’s previous personal best was $26.9 million with his 2006 Academy Awards champ “The Departed,” which also starred DiCaprio.

Along with “The Departed,” DiCaprio and Scorsese also worked together on “Gangs of New York” and “The Aviator,” both of them earning best-picture nominations at the Oscars.

Estimated ticket sales for Friday through Sunday at U.S. and Canadian theaters, according to Hollywood .com.

1. “Shutter Island,” $40.2 million.

2. “Valentine’s Day,” $17.2 million.

3. “Avatar,” $16.1 million.

4. “Percy Jackson & the Olympians: The Lightning Thief,” $15.3 million.

5. “The Wolfman,” $9.8 million.

6. “Dear John,” $7.3 million.

7. “The Tooth Fairy,” $4.5 million.

8. “Crazy Heart,” $3 million.

9. “From Paris With Love,” $2.5 million.

10. “Edge of Darkness,” $2.2 million.