Florida Shuttle Endeavour pulled away from the international space station on Monday and headed for home.
It culminated 12 days of shared work, the longest mission ever of its kind.
The 10 space travelers performed a record-tying five spacewalks, put together a space station robot and provided a new Japanese compartment, and a new resident, for the orbiting complex.
Astronaut Garrett Reisman flew up aboard Endeavour to replace French astronaut Leopold Eyharts, who was going home on the shuttle.
Endeavour is due back on Earth on Wednesday evening. It will wind up a 16-day trip for the shuttle.