Two Lawrence business owners were arrested and arraigned in U.S. District Court in Kansas City, Kan., after federal and local authorities arrived at their home Monday morning.

This is the second arrest for Guy Neighbors, 48, and Carrie Neighbors, 45, owners of the Yellow House Store, 1904 Mass. U.S. Postal Inspection Service and Internal Revenue Service agents are leading the investigation, authorities said Monday.

The couple had been arrested Dec. 12 at their home in the 1100 block of Andover Street on one count of possessing firearms while they “were unlawful users of a controlled substance.”

The charge was dismissed in May, when prosecutors said they planned to follow up on additional evidence.

An indictment unsealed Monday from U.S. Attorney Eric Melgren’s office revealed the latest charges against the Neighborses: Each faces one count of conspiracy to manufacture marijuana; one count of unlawful possession of a firearm by users of a controlled substance; and two counts of manufacturing marijuana.

According to the indictment, the crimes occurred between Feb. 22, 2002, and July 9, 2006, in Lawrence. A separate count seeks forfeiture of firearms, including 11 handguns, shotguns and rifles.

“This whole thing has been about firearms,” Guy Neighbors said in a telephone interview after he and his wife were arraigned Monday. “From what I’m looking at, a lot of the charges are the same as what was on the original list.”

If convicted, Guy and Carrie Neighbors each face a maximum penalty of 10 years in federal prison and a fine up to $250,000 on the firearms charges and a maximum penalty of five years and a fine up to $250,000 on each of the marijuana charges.

Jim Cross, Melgren’s spokesman, would not comment on whether additional charges will be filed.

A hearing is scheduled for 1:30 p.m. Aug. 13 before Chief Judge John W. Lungstrum in Kansas City, Kan.