Advertisement

Archive for Thursday, November 16, 2006

Scientists reconstruct part of Neanderthal DNA

November 16, 2006

Advertisement

— A small bone fragment that scientists initially ignored has produced a bonanza: enough Neanderthal DNA to start mapping the genetic code of the stocky and muscular relative of modern humans, scientists report.

Genetic material from the specimen has let researchers identify more than a million building blocks of Neanderthal DNA so far, and it should be enough to derive most of the creature's 3.3 billion blocks within the next two years, said researcher Svante Paabo.

"We're at the dawn of Neanderthal genomics," said gene expert Edward Rubin of the Lawrence Berkeley National Laboratory in Berkeley, Calif.

Such research will "serve as a DNA time machine that will tell us about the biology and aspects of Neanderthals that we could never get" otherwise, Rubin said.

And the Neanderthal data will shed light on what DNA changes helped produce modern humanity by revealing which changes appeared relatively late in human evolution, after the ancestors of Neanderthals and of humans split apart, scientists said.

Paabo, of the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, and colleagues present an initial analysis of Neanderthal DNA in this week's issue of the journal Nature. Rubin and his collaborators present their own analysis in this week's issue of Science.

A replica of a Neanderthal man is seen at the Neanderthal museum in Mettmann, western Germany. A small bone fragment has yielded enough Neanderthal DNA to start mapping the genetic code of the stocky and muscular relative of modern humans.

A replica of a Neanderthal man is seen at the Neanderthal museum in Mettmann, western Germany. A small bone fragment has yielded enough Neanderthal DNA to start mapping the genetic code of the stocky and muscular relative of modern humans.

Both are based on DNA extracted from a bone fragment only a couple inches long that lay in a Croatian cave for 38,000 years. It's not clear what kind of long bone the fragment came from, but DNA analysis indicated that it came from a male.

The two teams basically agree, within their margins of error, that the evolutionary lineages of Neanderthals and modern humans split somewhere around 500,000 years ago, he said. That number had been suggested by far more limited DNA analysis before, so it's comforting to see it backed up with more extensive study, he said.

Neanderthals and anatomically modern humans coexisted in Europe for thousands of years, until Neanderthals died out some 28,000 years ago. Scientists have been debating whether the two groups interbred and whether modern humans carry some genetic remnants of Neanderthals.

Rubin said his analysis, like some previous work, found no evidence of such intermixing, though it'll take more DNA to rule it out.

Paabo's analysis didn't directly address whether modern humans have DNA from Neanderthals, but it did raise speculation that DNA from anatomically modern humans might have found its way into Neanderthals. Scientists will have to examine more Neanderthal DNA to study that, he said.

Rubin also said analysis so far suggests human and Neanderthal DNA are some 99.5 percent to nearly 99.9 percent identical.

Comments

Use the comment form below to begin a discussion about this content.

Commenting has been disabled for this item.