Archive for Thursday, August 2, 2007

Experimental electrodes help brain-injured man

August 2, 2007

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This image provided by the Cleveland Clinic in Ohio shows the X-ray of a patient with deep brain stimulation leads implanted. It was used to help a man emerge from what doctors call a "minimally conscious state."

This image provided by the Cleveland Clinic in Ohio shows the X-ray of a patient with deep brain stimulation leads implanted. It was used to help a man emerge from what doctors call a "minimally conscious state."

— He was beaten and left for dead one night in a robbery while walking home in 1999. His skull was crushed and his brain severely damaged. The doctor said if he pulled through at all, he'd be a vegetable for the rest of his life.

For six years, the man could not speak or eat.

On occasion he showed signs of awareness, and he moved his eyes or a thumb to communicate. His arms were useless. He was fed through a tube.

But researchers chose him for an experimental attempt to rev up his brain by placing electrodes in it. And here's how his mother describes the change in her son, now 38:

"My son can now eat, speak, watch a movie without falling asleep," she said Wednesday while choking back tears during a telephone news conference. "He can drink from a cup. He can express pain. He can cry and he can laugh.

"The most important part is he can say, 'Mommy' and 'Pop.' He can say, 'I love you, Mommy' : I still cry every time I see my son, but it's tears of joy."

The progress of the patient, who remains unidentified at the family's request, is described more formally in a report in Thursday's issue of the journal Nature.

Experts called the results encouraging but cautioned that the experimental treatment must be tried in more patients before its value can be assessed. The researchers are already proceeding with a larger study.

Before the electrodes were implanted, the man was in what doctors call a "minimally conscious state." That means he showed only occasional awareness of himself and his environment. In a coma or vegetative state, by contrast, patients show no outward signs of awareness.

There are no reliable statistics on how many Americans are in a minimally conscious state, but one estimate suggests 112,000 to 280,000. Doctors may try medications to improve their condition, but no drugs have been firmly established as helpful.

The experimental treatment is called deep brain stimulation. It has been used for years in treating Parkinson's disease, although in this case the electrodes were implanted in slightly different places. The goal of the stimulation was to provide "drive" to areas of the brain that are critical for specific skills like speaking.

The man described in the Nature paper, despite his improvements, remains severely disabled in a rehabilitation facility for brain injury on the East Coast.

He can't walk. While he has regained the ability to chew and swallow, he must be spoon-fed.

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