Villanova's Antonio Pena, left, loses the ball as Louisiana State's Anthony Randoph defends. Villanova defeated LSU, 68-67, on Thursday night in Philadelphia.

Philadelphia ? Villanova’s only lead came on the shot that mattered most: the Wildcats’ last one.

Malcolm Grant converted a four-point play and scored 13 points over the final three minutes, and Dante Cunningham scored the game-winner with 5.9 seconds left as the 25th-ranked Wildcats rallied from a 21-point deficit to stun LSU, 68-67, on Thursday night in the Big East/SEC Invitational.

The Wildcats (6-1) seemed out of it after LSU dominated almost the entire game and most of the crowd had to started to leave. Instead, Villanova gave those who stuck around one to remember, rallying from the 21-point lead over the final eight minutes.

And it was all because of Grant, a 6-foot reserve guard.

Grant finished with 18 points and Cunningham had 16 points and 12 rebounds.

Marcus Thornton led LSU (5-3) with 15 points and 13 rebounds. Terry Martin hit four 3s to help the Tigers build the early lead and finished with 14 points.

The Wildcats return to the Top 25 appeared short-lived. Their shooting absolutely deserted them from all over the court and their starting backcourt couldn’t hit anything. Even the normally loyal, wine-and-cheese Wildcat faithful had turned on their favorite team with boos.

Enter Grant.

He converted a four-point play and came right back down and hit another 3-pointer that cut LSU’s lead to 56-53. The Wildcats forced a turnover at midcourt and scored a layup and suddenly they had a pulse.

Grant made four more free throws that pulled the Wildcats within three. Then he was amazingly fouled again on a 3-point attempt. This time the basket was no good, but he made all three from the line and LSU, which had led 54-33, was clinging to a 67-66 lead.

Grant tried to win it for the Wildcats on their last possession, but he missed a shot from the right side. Cunningham was there with the rebound layup that sent the crowd into a frenzy.

No. 13 Butler 53, Detroit 46

Detroit – Matt Howard scored 20 points and Julian Betko hit a late 3-pointer to help No. 13 Butler beat Detroit in the Horizon League opener for both teams.

Howard, a freshman center, scored 16 points in the second half – most of them near the basket – and finished with 11 rebounds and three blocks for the Bulldogs (8-0).

Jon Goode had 21 points and seven assists for the Titans (4-4), who lost their third straight to Butler. Betko’s 3-pointer with 2:45 to play gave the Bulldogs the lead for good.