Columbia, Mo. ? Michael Dixon scored 21 points to lead five Missouri players in double figures, and the seventh-ranked Tigers beat Iowa State, 78-72, on Wednesday night, clinching the No. 2 seed in next week’s Big 12 tournament.

Dixon’s driving layup with 3:36 left gave Missouri (26-4, 13-4) a 66-64 lead it wouldn’t relinquish. Marcus Denmon followed with a three-pointer, and Phil Pressey had a steal and layup with 1:23 remaining to cap a 7-0 run for the Tigers.

It was Missouri’s 13th Big 12 win, the most in school history as it prepares to leave for the Southeastern Conference next season. Scott Christopherson scored eight points in the final minute, including a three-pointer with 25.5 seconds remaining to close the deficit to 76-72. Dixon added two free throws with 15 seconds left.

Royce White led Iowa State (21-9, 11-6) with 20 points.