Columbia, Mo. ? James Franklin accounted for five touchdowns. Got humbled a bit, too.

Franklin threw three touchdown passes and ran for two touchdowns for Missouri in a 52-17 rout of Iowa State in the Tigers’ 100th homecoming game on Saturday. He was intercepted twice, one of them returned for a score, providing teaching points.

Michael Egnew, T.J. Moe and Wes Kemp each had a scoring reception for Missouri (3-3, 1-2 Big 12), which scored on its first four possessions. Much of a sellout crowd of 71,004 had dispersed by the end of the Tigers’ 10th straight victory at home, and their first game at Faurot Field in a month.

It was the most lopsided setback of the year for Iowa State (3-3, 0-3). A.J. Klein’s 78-yard interception return for a touchdown was the lone highlight for the Cyclones, who have been outscored 54-10 in the first quarter including 21 on Saturday.

The Cyclones lost by 23 points in each of their first two Big 12 games.