Richmond's Cedrick Lindsay, center, takes a shot against Vanderbilt during a Southwest regional second round NCAA tournament college basketball game, Thursday, March 17, 2011, in Denver.

Denver ? Richmond added another upset to an impressive NCAA tournament resume that already had several.

And Vanderbilt exited early — again.

Kevin Anderson scored 16 of his 25 points in the second half, including a floater with 18.7 seconds remaining that helped seal 12th-seeded Richmond’s 69-66 win against No. 5 seed Vanderbilt on Thursday in the Southwest regional.

The Spiders (28-7) sprang the second upset of the day at Pepsi Center after tiny Morehead State, the 13th seed, used a 3-pointer by Demonte Harper in the waning seconds to beat fourth-seeded Louisville, 62-61.

But while Morehead State players fell on the floor, writhing in the celebration, the Spiders simply shook hands and walked to the locker room. This hardly counts as a shocker, especially considering their history in March.

Richmond beat an Auburn team led by Charles Barkley during the 1984 NCAA tournament and picked off second-seeded Syracuse in 1991.

This is the Spiders’ first NCAA tournament win since they knocked out South Carolina in 1998 as a No. 14 seed, but the reputation has been cemented.

Maybe that’s why this win didn’t seem like all that big of surprise for the Atlantic-10 tournament champions, who were only a three-point underdog to the Commodores of the Southeastern Conference.

Justin Harper added 13 points and Francis-Cedric Martel contributed 12 as the Spiders won their eighth straight game.

“A very gutty effort by our team,” Richmond coach Chris Mooney said. “I thought our poise and veteran leadership really showed through in this game.”

Like many others around the nation, Mooney doesn’t quite see this win as an upset, especially given the fact that No. 12 seeds routinely knock off fifth seeds in the tournament.

“We have a program that can compete on a national level,” Mooney said. “We’re proud of our tradition and history. But at the same time, right now we feel like we’re a national program.”

Vanderbilt had a chance to tie with 2.5 seconds left, but Rod Odom’s desperation heave was nowhere near the hoop as time expired.

So much for the Commodores (23-11) vanquishing their tournament demons. They have now stumbled in their last three appearances in the NCAA, also losing to No. 13 seed Murray State on a last-second shot last season and falling to Siena, another 13th seed, in 2008.

They thought this could be the squad to end the drought.

But Vandy ran into a team that was every but its equal, despite what the seeds said.

“These teams are very, very close in talent and very close in ability,” Commodores coach Kevin Stallings said. “They have very good players, a very good system.

“We’re obviously very disappointed to have lost the game.”

Vanderbilt big man Festus Ezeli and John Jenkins, the SEC’s leading scorer, each finished with 21 points. Jenkins, though, was bottled up late in the second half, finding little room to unleash his quick jumper.

“We fought our hearts out. I can honestly say that,” Jenkins said. “We gave it our all. We just didn’t come out on the positive side today.”

The Commodores hurt themselves by never finding an answer for Anderson, a diminutive guard who came up big time and again for the Spiders, making 4 of 9 from 3-point range.

“My teammates did a good job of finding me,” Anderson said. “I was in the zone.”

Trailing 48-39 early in the second half, the Spiders worked their way back into the game behind the shooting of Anderson, the league tournament MVP. Anderson hit three straight 3-pointers at one point during a 12-0 run to give Richmond a 51-48 lead.

Brad Tinsley finally broke the dry spell for Vanderbilt with a short jumper. The Commodores went more than 4 minutes without a basket.

Vanderbilt tied the game at 55 on a 3-pointer by Tinsley with 8:15 remaining, but Richmond took the lead for good on two free throws from Harper.

Just when it looked like the game was all but over, Richmond kept Vandy’s hopes alive.

With Richmond up 68-65 and 5 seconds left, Darrius Garrett went to the line to secure the win. But he missed and Harper fouled Ezeli underneath the basket.

Ezeli made the first free throw and purposely clanged the second, the ball skittering into the corner where Anderson tracked it down. He was fouled and made 1 of 2 to restore a three-point lead.

Vanderbilt called timeout and moved the ball to halfcourt before calling another. The ball was inbounded to Odom, hardly the Commodores’ best option since he hadn’t attempted a 3-pointer all day.

His shot was well short and fell into the arms of Kevin Smith standing in the lane.

The Commodores led by as many as 11 points in the first half, only to see the Spiders storm back.

Vanderbilt has had trouble holding onto leads this season, blowing a big advantage in an SEC semifinal loss to Florida.

Waiting for the Spiders is a Morehead State team led by big man Kenneth Faried, the all-time rebounding leader in Division I. He secured the win for the Eagles by blocking Louisville’s last-second shot, setting in motion the festive celebration.

Meanwhile, Richmond took a much more subdued approach.

“We want to keep looking further into the tournament, not just be satisfied with this win,” Anderson said. “We won one game. But we didn’t win the tournament. That’s our ultimate goal.”

Even upset specialists can think big.