Injuries have changed the landscape of college basketball as players sitting on the bench in street clothes have had as big of an impact as players on the court.

Injuries can also do more than just deplete depth, they can completely change the way teams play the game — as they have for reigning national champion Duke.

Here’s a look at six injuries — or in some cases, sets of injuries — that have had the biggest impact on college basketball this season.

Kyrie Irving, Duke

At first glance, it seemed Irving had merely tweaked an ankle or had a cramp when he came up limping late in Duke’s eighth game. Days later, coach Mike Krzyzewski said the star freshman point guard was out indefinitely — and maybe the season — due to an injured right big toe. Irving averaged 17 points, but more importantly, was the trigger of the Blue Devils’ up-tempo offense and transition game.

Doctors were set to remove Irving’s cast Friday, but Krzyzewski has said he’s focused on Irving’s long-term recovery and hasn’t sounded overly optimistic about his return.

Robbie Hummel, Purdue

The Boilermakers reached No. 3 last season before the 6-foot-8 forward who was the team’s second-leading scorer and rebounder suffered a torn right anterior cruciate ligament. His return figured to make Matt Painter’s squad a Final Four contender. In the first preseason practice, the senior landed awkwardly when he went for a block and heard a familiar pop as the same knee gave out again.

Abdul Gaddy, Washington

The point guard ranked No. 2 in his class behind John Wall was showing improvement for the 20th-ranked Huskies after a disappointing freshman season. But he suffered a torn left ACL in practice during a January scrimmage after staring the first 13 games. The 6-foot-3 sophomore was averaging 8.5 points and 3.8 assists while showing improved command of the offense. Coach Lorenzo Romar felt he had enough depth with leading scorer Isaiah Thomas and Venoy Overton, but Gaddy was “probably the best at just settling us down and getting us in the offense.”

Al Nolen, Minnesota

The senior guard went down with a broken right foot against Michigan on Jan. 22, an injury that required surgery to place a pin in the foot.

Dorenzo Hudson, J.T. Thompson and Allan Chaney, Virginia Tech

Thompson, a senior sixth man, tore his left ACL in preseason. Chaney has yet to play after transferring from Florida and is out indefinitely as he recovers from a viral infection in his heart. Then Hudson — a two-year starting guard who averaged about 15 points last year — played just nine games before having season-ending surgery on a foot injury. That leaves a lot of pressure on Malcolm Delaney and Jeff Allen as the Hokies try to fight their way out of the jumbled middle of the ACC standings.

Maurice Creek and Christian Watford, Indiana

First Creek — a 6-5 guard — was sidelined last month due to a stress fracture in his right kneecap that required season-ending surgery.

Then, on Tuesday, coach Tom Crean said Watford — a 6-9 forward averaging a team-best 17 points and 5.8 rebounds — was out indefinitely after having surgery on a broken left hand.