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Archive for Saturday, December 4, 2010

Scientists reverse signs of aging in mice

December 4, 2010

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— Have scientists finally discovered the genetic fountain of youth? Hardly. But by creating a genetic switch that allows them to artificially age — and rejuvenate — lab mice, scientists have shown that it is possible to reverse some effects of aging in mammals.

“It indicates there’s a point of return if you remove the underlying cause of the aging,” said Dr. Ronald DePinho, the molecular biologist at the Dana-Farber Cancer Institute at Harvard Medical School who led the study, published online earlier this week in the journal Nature.

Scientists know that some of the signs of aging in humans are associated with telomeres, repetitive strands of DNA that protect the ends of chromosomes.

Telomeres “are like the caps on your shoelaces — they help maintain the package of your chromosomes,” DePinho said.

As cells divide and replicate, these chromosome protectors get worn down and frayed over time. And with age, as telomeres shorten, signs of age-related degeneration — from graying hair to infertility to organ failure — emerge.

To figure out if this process could be reversed, the scientists first engineered mice that aged artificially fast. In these rodents, the team had suppressed the gene that makes telomerase, an enzyme partly responsible for the repair of telomeres.

With prematurely shortened telomeres, the mice’s coats grayed, their spleens atrophied and their brains and testes shrunk. Their skin was plagued by dermatitis and their sense of smell dulled. In short, they showed many signs of aging. At a normally youthful 6 months, they already looked 2 years old, DePinho said — equivalent to a human octogenarian.

The scientists then administered a drug that switched the suppressed telomerase gene back on. Soon enough, the mice regained the sheen in their coats, sensitivity in their noses and the sperm in their testes. The signs of age seemed to slough off them.

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