The Rocky Mountain News, Colorado’s oldest newspaper and a Denver fixture since 1859, will publish its last edition today.

Owner E.W. Scripps Co. said Thursday the newspaper lost $16 million last year and the company was unable to find a buyer.

“Today the Rocky Mountain News, long the leading voice in Denver, becomes a victim of changing times in our industry and huge economic challenges,” Scripps CEO Rich Boehne said.

The News is the latest — and largest — newspaper to fail amid a recession that has been especially brutal for the industry. Four owners of 33 U.S. daily newspapers have sought Chapter 11 bankruptcy protection in the past 2 1/2 months. A number of other newspapers are up for sale.