Norman, Okla. Sam Bradford overcame two interceptions and threw for a career-best 395 yards and five touchdowns and No. 4 Oklahoma overpowered Cincinnati, 52-26 Saturday.
Freshman Ryan Broyles had a breakout game with 141 receiving yards, Jermaine Gresham caught two touchdown passes and OU extended the nation's longest home winning streak to 20 games.
Broyles had a 27-yard touchdown reception in the first quarter and extended a key second-half drive with a leaping 43-yard catch to allow the Sooners (2-0) to start pulling away with 24 consecutive points.
For Bradford, who led the nation in quarterback rating last season, it was the third time he tied the school record for TD passes held by 2003 Heisman Trophy winner Jason White and 2000 Heisman runner-up Josh Heupel. His only other two-interception game came in an upset loss last season at Colorado.
Cincinnati's Mardy Gilyard, who tallied a school-record 365 all purpose yards, returned a kickoff 97 yards for a touchdown to break one of the longest runback droughts in college football. The last score by the Bearcats (1-1) on a kickoff return came in 1995, and only two schools have gone longer than Cincinnati's 145 games without one.
Oklahoma led, 28-20, after Gilyard's runback in the third quarter, but DeMarco Murray went untouched on an 11-yard touchdown run and then Cincinnati coach Brian Kelly's bag of tricks backfired.
He'd already run a failed Statue of Liberty play - reminiscent of Boise State's Fiesta Bowl win in 2007 against Oklahoma - near the goal line and a botched wide receiver pass when J.R. Bryant jumped to bat down punter Kevin Huber's pass on a fake.