Colts 31, Texans 27

Houston – Peyton Manning turned a colossal collapse by the Texans into a stunning victory for the Colts.

The Colts scored 21 points in a late span of 2:10 – two touchdowns thanks to fumbles by Sage Rosenfels – then intercepted Rosenfels’ last-ditch comeback attempt for a victory Sunday.

Manning threw two touchdown passes, connecting with Reggie Wayne on a five-yarder with 1:54 remaining for the decisive points.

Cardinals 41, Bills 17

Glendale, Ariz. – The Bills lost their quarterback and, emphatically, their first game of the season. Second-year quarterback Trent Edwards went down with a concussion on a fierce hit from safety Adrian Wilson on the third play of the game.

Steelers 26, Jaguars 21

Jacksonville, Fla. – Ben Roethlisberger threw for 309 yards and three touchdowns.

Broncos 16, Buccaneers 13

Denver – The high-flying Broncos finally discovered a defense, generating a pass rush that sent Brian Griese to the sideline due to an injured throwing shoulder.

Cowboys 31, Bengals 22

Irving, Texas – After letting a 17-point lead shrivel to one, then breaking up a two-point conversion that could’ve tied it, the Cowboys had plenty of reasons to celebrate. Dallas (4-1) led, 17-0, after only three drives, but ended up needing big plays from Terrell Owens, Tank Johnson and Keith Davis to stave off the bumbling Bengals (0-5).

Patriots 30, 49ers 21

San Francisco – From Randy Moss’ dynamic 66-yard touchdown catch to Kevin Faulk’s score on a direct snap, the Patriots returned to their usual regular-season form.

Dolphins 17, Chargers 10

Miami – The Dolphins are winning the old-fashioned way. The single wing helped build a lead, and a goal-line stand preserved it.

Titans 13, Ravens 10

Baltimore – Kerry Collins threw an 11-yard touchdown pass to Alge Crumpler with 1:56 left.

Giants 44, Seahawks 6

East Rutherford, N.J. – Eli Manning threw two touchdowns and Brandon Jacobs ran for two more.

Falcons 27, Packers 24

Green Bay, Wis. – Matt Ryan completed 16 of 26 passes for 194 yards, two touchdowns and an interception.

Redskins 23, Eagles 17

Philadelphia – Clinton Portis ran for 145 yards and one touchdown, and wide receiver Antwaan Randle El threw a TD pass.

Bears 34, Lions 7

Detroit – Kyle Orton set career highs in yards passing, completions and QB rating while throwing two TDs.