Greg Maddux has thrown his last pitch.

The four-time Cy Young winner will announce his retirement Monday at the baseball winter meetings in Las Vegas.

Maddux, who turns 43 in April, ranks eighth on the career wins list with 355. He went 8-13 with a 4.22 earned-run average last season with the San Diego Padres and Los Angeles Dodgers.

Maddux made three relief appearances in the playoffs for the Dodgers this year — he had an 0.00 ERA over four innings — and then filed for free agency amid speculation he would retire.

On Friday, confirmation came from the office of Maddux’s agent, Scott Boras. Maddux, his family and Boras will hold a news conference at the hotel where the meetings are being held to announce one of baseball’s greatest pitchers is finished.

Last month, Dodgers general manager Ned Colletti left open the possibility that Maddux would return for a 24th season in the majors.

Maddux finished one win ahead of Roger Clemens on the career victory list. Overall, “Mad Dog” was 355-227 with a 3.16 ERA, and is considered a certain first-ballot Hall of Famer when he becomes eligible after five years.