Here’s what Plaxico Burress has given the New York Giants since they gave him a five-year, $35-million contract extension to start this season — a massive, needless migraine.

A series of them actually, leading now to an apparently self-inflicted gunshot wound late Friday night in a Manhattan nightclub, from a gun the talented wide receiver reportedly was carrying illegally.

The pain, to say nothing of the madness, needs to stop.

The Giants need to do what they must do to cut their losses on Burress, 31, and wish him a nice football life with anyone who is willing to deal with his inexplicable, self-destructive nonsense.

Burress is no Michael Vick. Until now, his professional offenses have been mostly annoying, nuisance stuff: missing or being late for meetings, pouting over his contract and sitting out minicamp, popping off about officials. Immature acting out that made you want to shake Burress and ask him why he seemed bent on spoiling his new-found respect and good fortune.

While they have punished him along the way, the Giants at the same time have been willing to swallow Burress’ quirks and oddities, for good reason. Burress is a superb talent.

At 6-foot-5, the former first-round draft pick has established himself as a unique offensive weapon. Playing through season-long pain from various injuries, he caught the winning pass in last season’s Super Bowl. Two weeks before that he played one of the great playoff games in league history in frigid Green Bay, catching 11 passes as the Giants won the conference.

That said, Burress, since agreeing to his new contract on opening night, has been suspended by the Giants for missing a meeting and being weirdly incommunicado about it. He has been docked more than $200,000 by both his team and the NFL for boorish or belligerent behavior.

In a season in which the Giants are 10-1 and steaming toward the NFC East title and another playoff run, it’s as if Burress has been in one place while the rest of the Giants have been somewhere else, a better place way over there.

No question, Burress marches to a different beat and does so unapologetically. The league is full of divas such as Burress who do likewise. As a fan, you get used to egomaniacal eccentrics.

But discharging a gun, accidentally or not, in a public place is something far different. Felony gun charges, which Burress could be facing, go further than not caring about convention.

On a fundamental level, Burress put himself in a position to endanger others. On a professional level, his misadventures have eaten at the team unity the Giants have built and have used so well in rallying to last year’s title and positioning themselves as the favorites to win another Super Bowl.

How can dragging Burress along with them be worth the distraction and conflict anymore? Burress has caught just 35 passes and scored four touchdowns — pedestrian numbers — since he agreed to his new contract.

It’s true Burress regularly draws double coverage from defenders, and that has helped the Giants develop the league’s most potent rushing attack. Still, the Giants as a franchise are clearly bigger and better than Burress, and they need to show it now by severing their relationship.