New York Jelena Jankovic outlasted Sweden's Sofia Arvidsson, 6-3, 6-7 (5), 7-5, Wednesday on yet another uncharacteristically mild August day in Flushing Meadows.
Eighth-seeded Andy Roddick, who has battled a shoulder injury this summer that led him to skip the Beijing Olympics, won his first match in straight sets. He beat Fabrice Santoro - the oldest man in the draw at 35 - 6-2, 6-2, 6-2.
While Jankovic escaped an early exit, No. 8 seed Vera Zvonareva couldn't. Zvonareva was upended by Tatiana Perebiynis, 6-3, 6-3, in the tournament's biggest upset yet.
No. 3 Svetlana Kuznetsova shook off an early break and rallied to a 7-6 (3), 6-1 victory over Sorana Cirstea.
In men's first-round play, No. 3 seed Novak Djokovic shook off an injury to his left ankle in the third set and beat Arnaud Clement, 6-3, 6-3, 6-4.