Minneapolis – Brett Favre was as good as ever, becoming the NFL’s career leader in touchdown passes with a couple of vintage third-down zingers to help Green Bay stay unbeaten.

Favre was the obvious difference in Sunday’s 23-16 victory by the Packers (4-0), who hung on against the pass-deficient Minnesota Vikings.

He threw No. 421 in the first quarter to Greg Jennings and No. 422 in the fourth quarter to James Jones and went interception-free against a defense determined to make him the league’s career leader in that category, too. Favre remained three picked-off passes away from passing George Blanda.

Cowboys 35, Rams 7

Irving, Texas – Tony Romo had a 15-yard touchdown run and threw touchdown passes of 59, 37 and 17 yards, turning what had been a tight early game into yet another easy victory for Dallas and another frustrating loss for St. Louis.

The Cowboys are 4-0 for the first time since 1995, the year of their last Super Bowl title. The Rams are 0-4 for the first time since 2002, when they opened with five straight defeats coming off a Super Bowl loss.

Romo was 21-of-33 for 339 yards and three touchdowns, with an interception.

Raiders 35, Dolphins 17

Miami – Daunte Culpepper ran for three touchdowns and threw for two to win the grudge game against his former team. His much-scrutinized knee might not be 100 percent, but it was good enough to lead the Raiders.

For the second time in four years, the Dolphins are 0-4.

Culpepper threw only 12 times and completed five for 75 yards, but hit Jerry Porter for scores of 7 and 27 yards. Justin Fargas replaced an injured LaMont Jordan shortly before halftime and ran for a career-high 179 yards in 22 carries.

Falcons 26, Texans 16

Atlanta – Joey Harrington threw a pair of touchdown passes to Michael Jenkins, 47-year-old Morten Andersen kicked four field goals, and the Falcons defeated Matt Schaub and the Texans.

Jenkins hauled in scoring passes of 5 and 7 yards, the first two-touchdown game of his up-and-down career. Harrington, who took over as starter after Schaub was traded and Michael Vick became embroiled in a dogfighting case, was 23-of-29 for 223 yards.

Schaub was 28-of-40 for 317 yards, including a 35-yard touchdown pass to Andre’ Davis that gave Houston (2-2) a short-lived lead in the first quarter. But the Texans couldn’t punch in their other scoring chances, settling for field goals by Kris Brown.

Browns 27, Ravens 13

Cleveland – Derek Anderson threw two touchdown passes, and Jamal Lewis ran for one against his former team.

With their second victory over a division opponent this month, the Browns (2-2) looked nothing like the inept team that was embarrassed 34-7 in their home opener three weeks ago by Pittsburgh.

Lewis, released by Baltimore coach Brian Billick in March, got some satisfaction against his former coach and the team he played with for seven years. He finished with 64 yards and scored on a disputed dive in the second quarter, the first TD rushing given up by the NFL’s top run defense this season.

Bills 17, Jets 14

Orchard Park, N.Y. – Making his first career start in place of injured J.P. Losman, Trent Edwards went 22-of-28 for 234 yards, including a 1-yard touchdown to Michael Gaines with seven minutes left.

With the third-round draft pick, the Bills produced their most points, total yards (304), yards passing and first downs (19) of the season and helped erase the frustrations of an 0-3 start.

Lions 37, Bears 27

Detroit – Jon Kitna threw two touchdown passes in the fourth quarter, and Detroit overcame mistakes and missed opportunities to beat Chicago.

Brian Griese, who had two TDs and three interceptions as a starter in place of Rex Grossman, threw a 1-yard pass to Desmond Clark on a fourth down with 52 seconds left to pull the Bears within three points. However, the onside kick bounced to Detroit’s Casey FitzSimmons, and he returned it for a TD.

Chicago’s Devin Hester returned a kickoff 97 yards, his seventh kick or punt return for a score in one-plus seasons.

Colts 38, Broncos 20

Indianapolis – Indianapolis relied on flawless execution to score on six of its last eight possessions, adding yet another anguishing chapter to Denver’s recent rivalry with Indy.

The Colts have won five of seven in the series since Tony Dungy took over as coach and extended their league-best winning streak to nine when counting last year’s playoff games.

Despite overpowering the Colts with its usually efficient ground game in the first half, Denver lost for the second straight week. For a while, it appeared the Broncos had a winning combination, but the Colts’ Peyton Manning and Joseph Addai ruined everything.

Cardinals 21, Steelers 14

Glendale, Ariz. – The Steelers were beaten at their own game by their old offensive coordinator and might-have-been head coach.

Rookie Steve Breaston returned a punt 73 yards for a touchdown, and the Cardinals’ defense shut down Pittsburgh’s high-scoring offense most of the day to hand the Steelers their first loss.

Arizona first-year coach Ken Whisenhunt and top assistant Russ Grimm both were leading contenders to replace Bill Cowher in Pittsburgh after last season. Instead, the job went to Mike Tomlin.

Seahawks 23, 49ers 3

San Francisco – Matt Hasselbeck passed for 281 yards and two touchdowns, Rocky Bernard ended Alex Smith’s day early with a punishing sack, and the Seahawks claimed early supremacy in the NFC West.

Deion Branch had seven catches for 130 yards for the Seahawks, who snapped a two-game losing streak against San Francisco.

Bernard made the biggest of Seattle’s six first-half sacks on San Francisco’s third play from scrimmage, piledriving Smith with every ounce of his 308-pound frame. The impact injured Smith’s right shoulder seriously enough to keep him out the rest of the day. He was replaced by Trent Dilfer.

Buccaneers 20, Panthers 7

Charlotte, N.C. – Jeff Garcia didn’t throw an interception for the fourth straight game and ran for a touchdown, while Tampa Bay shut down David Carr, Steve Smith and Carolina to move atop the NFC South.

The 37-year-old Garcia, signed in the offseason, completed 15 of 25 passes for 176 yards and got Tampa Bay on the board with a 3-yard scramble on the Bucs’ first possession.

Ike Hilliard caught seven passes for 114 yards, Michael Pittman rushed for 90 yards, and the Buccaneers overcame the loss of running back Carnell “Cadillac” Williams to a right knee injury to beat the Panthers for only the second time in nine meetings.

Giants 16, Eagles 3

East Rutherford, N.J. – With Hall of Famer Lawrance Taylor on the sidelines as an honorary captain, it was appropriate that the New York Giants sacked the Philadelphia Eagles unmercifully.

Osi Umenyiora had a team-record six sacks, and the Giants set a franchise record and tied a league record by sacking Donovan McNabb 12 times.

Mathias Kiwanuka added three sacks, Justin Tuck two and Michael Strahan one in an awesome display by a defense that was ranked as the worst in the league after giving up 80 points in its first two games.