Florida ? Dr. J. Robert Cade, who invented the sports drink Gatorade and launched a multibillion-dollar industry that the beverage continues to dominate, died Tuesday of kidney failure. He was 80.

His death was announced by the University of Florida, where he and other researchers created Gatorade in 1965 to help the school’s football players replace carbohydrates and electrolytes lost through sweat while playing in swamp-like heat.

Now sold in 80 countries in dozens of flavors, Gatorade was born thanks to a question from former Gators Coach Dwayne Douglas, Cade said in a 2005 interview with The Associated Press.

He asked, “Doctor, why don’t football players wee-wee after a game?”

“That question changed our lives,” Cade said.