Iran ? “Hollywood declares war on Iranians.”

That’s the headline in the independent Ayende-No newspaper Tuesday as Iran reacted with anger to the Greeks-versus-Persians blockbuster “300.”

Javad Shamghadri, cultural adviser to Iranian President Mahmoud Ahmadinejad, said the United States tries to “humiliate” Iran in order to reverse historical reality and “compensate for its wrongdoings in order to provoke American soldiers and warmongers” against Iran.

Iran’s biggest circulation newspaper, Hamshahri, said “300” is “serving the policy of the U.S. leadership” and predicted it will “prompt a wave of protest in the world. … Iranians living in the U.S. and Europe will not be indifferent about this obvious insult.”

The movie, which raked in $70 million in its opening weekend, is based on a comic-book fantasy version of the battle of Thermopylae in 480 B.C., in which a force of 300 Spartans held off a massive Persian army at a mountain pass in Greece for three days.