Alabama ? A sport utility vehicle traveling the wrong way on an interstate collided head-on with a Greyhound bus early Friday, killing the SUV’s driver and injuring 46 people, police said.

The bus driver and all 53 passengers were taken to a hospital, with 45 treated and released and one admitted in serious but stable condition. Mayor Bobby Bright said none of the injuries appeared life-threatening.

The driver, Joseph Rudder, 45, was alone in the SUV, which was headed north in the southbound lane, police Capt. Huey Thornton said. Authorities weren’t certain why the SUV was traveling the wrong way.