Syracuse, N.Y. Notre Dame became the first team to crack the century mark in the Carrier Dome in 10 years.
After missing their first three three-pointers, the No. 21 Irish went 10-for-14 from behind the arc to close the opening half and beat the Orange, 103-91, on Tuesday night.
"We got off to a great start and played fearlessly and with great unselfishness," Notre Dame coach Mike Brey said. "We're good offensively. We can put numbers on the board."
West Virginia was the last team to score 100 in Syracuse, beating the Orange, 101-79, on Dec. 4, 1996.
Syracuse abandoned its signature 2-3 zone defense for most of the game because of the tough matchups the Irish provided. But whatever defensive alignment the Orange chose proved no match for the Irish, who even played without 6-foot-9 Rob Kurz (sprained ankle), their second-leading scorer at 14 points per game and leading rebounder at 8.8 per game.
Russell Carter and Colin Falls more than made up for his absence. Each hit four three-pointers and combined for 29 points in the opening period, and most were wide-open looks against the defenseless Orange.
"We had to play them man-to-man, and we couldn't do it," Syracuse coach Jim Boeheim said. "Inside, we had no effort until the end of the game. That's just not going to get it done. The only thing that was a positive is we keep trying."
Notre Dame (18-4, 6-3 Big East) won for the first time in four conference road games and halted a three-game losing streak against the reeling Orange (15-7, 4-4), who lost their third straight game.
"This was big to come out and get a road win, especially coming here," said freshman Luke Harangody, who had 21 points and 13 rebounds.