Former Detroit running back Barry Sanders acknowledges the crowd as he enters Ford Field. The Lions were celebrating the 10th anniversary of Sanders' 2,053-yard rushing season at halftime of a 25-20 victory Sunday over the Kansas City Chiefs.

Cleveland QB Derek Anderson walks off the field after the Browns' 19-14 loss to Cincinnati on Sunday.

Indianapolis Colts safety Bob Sanders (21) celebrates with cornerback Marlin Jackson (28) after intercepting a pass during the first quarter of the Colts' 38-15 victory over Houston on Sunday in Indianapolis.

New England Patriots running back Laurence Maroney (39) takes off on a second-quarter touchdown run against the Miami Dolphins. The Pats won, 28-7, Sunday in Foxborough, Mass.

Foxborough, Mass. ? Patriots 28, Miami 7

The Patriots set an NFL record with their 15th victory. Tom Brady and Randy Moss edged closer to two more marks.

And New England still has one game left to reach an even more amazing goal: the first team to finish a regular season undefeated in 35 years.

Brady threw three touchdown passes, two to Moss, and the Patriots beat Miami, 28-7, on Sunday to improve to 15-0, the best start in league history. The old mark: Miami’s 14-0 in 1972 when the season lasted just 14 games.

If the Patriots beat the New York Giants at the Meadowlands Saturday, then go unbeaten in the postseason to finish 19-0, they’ll join the Dolphins as the only teams to post a perfect record from opening day until the clock in the championship game runs out.

Brady has 48 touchdown passes, one shy of Peyton Manning’s NFL record of 49 set in 2004 and tied with Dan Marino’s production in 1984.

Moss reached 21 touchdown receptions, one less than Jerry Rice’s mark of 22 set in 12 games in 1987, a strike year.

Jaguars 49, Raiders 11

Jacksonville, Fla. – Fred Taylor’s 62-yard touchdown run on Jacksonville’s opening play set the tone for a rout that propelled the Jaguars into the playoffs.

Taylor finished with 111 yards as the Jaguars (11-4) won for the sixth time in seven games and clinched the No. 5 seed in the AFC playoffs.

The Raiders (4-11), who took their worst loss of the season, finally turned things over to No. 1 draft pick JaMarcus Russell. Russell was 7-of-23 for 83 yards with a touchdown – a two-yard pass to Zach Miller with six seconds remaining – three interceptions and a fumble.

Giants 38, Bills 21

Orchard Park, N.Y. – The Giants clinched a playoff berth by overcoming a Bills team inspired by Kevin Everett’s return to the field where he was injured.

Brandon Jacobs scored twice, and Ahmad Bradshaw had an 88-yard TD run in sloppy conditions as the usually pass-happy Giants (10-5) leaned heavily on their running attack.

Everett, the Bills tight end nearly paralyzed in the season-opening loss to the Broncos, is now walking on his own and watched the ugly game from a suite near midfield.

Titans 10, Jets 6

Nashville, Tenn. – The Titans are back in control of their chase for their first playoff berth since 2003. Pro Bowler Kyle Vanden Bosch had three of Tennessee’s six sacks, and Chris Brown ran for a touchdown.

The Titans (9-6) have the edge over Cleveland in tiebreakers if tied for the AFC’s final wild-card berth. They still must close out the season with a victory at Indianapolis.

Bengals 19, Browns 14

Cincinnati – Derek Anderson’s consecutive interceptions set up a pair of rapid-fire touchdowns late in the first half, and he threw four in all in a loss that left the Browns scrambling for a playoff spot.

Cleveland (9-6) could have clinched with a victory over the down-and-out Bengals (6-9), who had nothing more than pride on the line and several starters out with injuries. With Cleveland’s loss, the Pittsburgh Steelers clinched the AFC North title.

Eagles 38, Saints 23

New Orleans – Donovan McNabb passed for 263 yards and three touchdowns, jeopardizing the Saints’ chances for making the playoffs.

McNabb no longer showed any effects of his rehabilitation from knee surgery over the summer or an ankle sprain in midseason. His 40-yard scramble on the third play led to a bizarre touchdown after his fumble was recovered in the end zone by Kevin Curtis.

McNabb also had TD passes of 31 yards to Reggie Brown and seven yards to Curtis.

Drew Brees threw for 289 yards and an interception and lost his best receiver when Marques Colston left the game in the first half due to a chest contusion.

Seahawks 27, Ravens 6

Seattle – Matt Hasselbeck shook off two interceptions to throw two touchdown passes, and Shaun Alexander had his biggest rushing day since Week 4 as the Seahawks clinched the No. 3 seed in the NFC.

Hasselbeck’s scores gave him a career-high 27 TDs this season. One went to Alexander, on a screen pass of 14 yards. That gave Seattle (10-5) a 21-0 lead in the first half.

Colts 38, Texans 15

Indianapolis – Peyton Manning threw three touchdown passes, Joseph Addai and Clifton Dawson ran for TDs, and the Colts scored on six of their first eight possessions.

In what was likely to be the last significant action for Indy’s starters until mid-January when the AFC’s No. 2 seed will play in the divisional round of the playoffs, Manning & Co. finished with 458 yards, scored 38 unanswered points and won their sixth in a row.

49ers 21, Bucs 19

San Francisco – Shaun Hill passed for three touchdowns to remain unbeaten as an NFL starter, and Michael Clayton landed out of bounds with his catch on a two-point conversion attempt with 1:20 left for Tampa Bay (9-6).

Jeff Garcia passed for 196 yards and a touchdown against his former team before coach Jon Gruden removed him and most of the Buccaneers’ playmakers late in the first half, apparently to rest the NFC South champions, who’ll be the fourth seed, for a playoff game in two weeks.

Bears 35, Packers 7

Chicago – Green Bay (12-3) can forget about the No. 1 seed in the NFC, which Dallas now owns.

Brian Urlacher returned an interception for a touchdown for the first time in his career, going 85 yards, and Adrian Peterson ran for 102 yards on a frigid afternoon.

Brett Favre was at his worst on a bone-chilling, windy and at times snowy afternoon, and the Packers took their second loss at the hands of their archrivals. He passed for just nine yards in the first half and 153 overall, giving him 4,058 this season and putting him over the 4,000-yard mark for the fifth time.

He was 17-for-32 and threw two interceptions. Alex Brown picked him off on the first possession of the third quarter, setting up a touchdown that made it 21-7, and Urlacher ran his back early in the fourth period.

The Bears (6-9) blocked two punts by Jon Ryan, who also dropped a snap and booted a nine-yarder.

Cardinals 30, Falcons 27, OT

Glendale, Ariz. – Neil Rackers kicked a 29-yard field goal to force overtime, then booted one from 31 yards on the first possession of the extra session. Rackers celebrated by sliding on his knees across the grass. He had missed what would have been a game-winning 32-yarder against San Francisco earlier this season.

Kurt Warner completed 36 of 53 passes for 361 yards and three touchdowns, two to Anquan Boldin, who caught 13 for 162 yards. Boldin became the fastest to reach 400 career catches in NFL history.

Redskins 32, Vikings 21

Minneapolis – Playing the kind of hard-nosed, harder-hitting defense that fallen teammate Sean Taylor was famous for, the Redskins shut down Adrian Peterson and set up two early touchdowns with interceptions to take control of their playoff fate.

Todd Collins was 22-for-29 for 254 yards and two touchdowns, and Clinton Portis had 124 total yards, threw a TD pass and ran for another score for the Redskins (8-7), who can clinch a playoff spot with a win over Dallas next week.

Peterson gained just 27 yards on nine carries in the loss. Tarvaris Jackson’s rebound from a difficult start came too late for the Vikings (8-7), who could have clinched a playoff berth with a win.