Yankees 6, Indians 1

Cleveland – Alex Rodriguez hit career home run No. 501, and rookie Phil Hughes dominated Cleveland for six innings. Rodriguez, who became the youngest player to reach the 500-homer plateau last week, connected for his 37th homer in the second inning off Fausto Carmona (13-7).

The shot to straightaway center set the tone for the Yankees, who have been beating up on some of the AL’s weaker teams lately.

Before coming to Central-leading Cleveland, New York had played 28 straight games against teams that had losing records at the All-Star break. The Yankees improved to 21-8 since July 12.

Hughes (2-1) was hardly challenged by the Indians, whose offense has been sputtering for weeks. The right-hander allowed one run and four hits in six innings. It was just his second start since spending three months on the disabled list.

Athletics 16, Tigers 10

Detroit – Jack Cust hit a grand slam and drove in seven runs, and Oakland rallied after blowing a seven-run lead. Travis Buck had four hits, scored three times and drove in three runs for Oakland. Donnie Murphy homered and drove in three runs as the A’s handed Detroit its seventh loss in nine games. The Tigers are 11-18 since the All-Star break.

Orioles 6, Red Sox 5

Baltimore – Brian Roberts led off the ninth inning with a double and scored the game-winning run on a sacrifice fly by Nick Markakis, giving Baltimore a comeback victory over Boston.

The Orioles rallied from a 5-1 deficit with a four-run eighth against Eric Gagne, then won it in the ninth against Hideki Okajima (3-1).

Baltimore rookie Jim Hoey (1-0) got four outs to earn his initial big league win.

Rangers 7, Devil Rays 4

Arlington, Texas – Frank Catalanotto hit the go-ahead homer and had a career-high five RBIs to lead Texas over Tampa Bay. With the Rangers trailing 3-2 in the fifth, Catalanotto’s three-run blast put Texas ahead for good. Catalanotto added a two-run single in the sixth to pad the lead to 7-4.

White Sox 5 Mariners 3

Chicago – Rookie Josh Fields hit two homers, Jermaine Dye went deep, and Juan Uribe doubled in the go-ahead run in the seventh.

Angels 10, Twins 1

Anaheim, Calif. – Maicer Izturis hit his first career grand slam to help Kelvim Escobar end a personal three-game losing streak.