Georgia and Miami have a chance to right their shaky seasons and jump back into the Top 25.
Georgia faces rival Florida on Saturday in Jacksonville, Fla..
The Bulldogs are two-touchdown underdogs in the World's Largest Outdoor (please don't call it a cocktail) Party.
Miami travels to Atlanta to face Georgia Tech.
A victory for the beleaguered Hurricanes would vault them into first place in the ACC's Coastal division.
No. 10 Clemson (minus 41â2) at Virginia Tech
Tigers TBs James Davis and CJ Spiller have combined for 23 rushing TDs ... CLEMSON 35-17.
Minnesota (plus 27) at No. 1 Ohio State
Buckeyes have 15-game win streak ... OHIO STATE 42-13.
Northwestern (plus 34) at No. 2 Michigan
Wildcats are Wolverines' homecoming opponent for sixth time ... MICHIGAN 38-10.
No. 3 Southern California (minus 12) at Oregon State
USC's last game of season outside California ... USC 28-17.
No. 5 Texas (minus 111â2) at Texas Tech
Longhorns ranked 84th in the country against the pass ... TEXAS 44-24.
No. 7 Auburn (minus 181â2) at Mississippi
Tigers have won last six games at Oxford ... AUBURN 30-14.
No. 8 Tennessee (minus 5) at South Carolina
Gamecocks coach Steve Spurrier has won 10 of 14 against Vols ... TENNESSEE 28-24.
No. 9 Florida (minus 14) vs. Georgia at Jacksonville, Fla.
Last four meetings have been decided by seven points or less. ... FLORIDA 23-14.
No. 11 Notre Dame (minus 14) vs. Navy at Baltimore
The Fighting Irish have won 41 straight against Navy ... NOTRE DAME 44-21.
Louisiana-Monroe (plus 37) vs. No. 13 Arkansas at Little Rock, Ark.
Razorbacks are sixth in nation in rushing ... ARKANSAS 52-13.
Illinois (plus 21) at No. 17 Wisconsin
Badgers are seventh in nation in total defense ... WISCONSIN 36-10.
Buffalo (plus 36) at No. 18 Boston College
Banged-up BC QB Matt Ryan expected to play ... BOSTON COLLEGE 48-10.
No. 19 Oklahoma (plus 21â2) at No. 23 Missouri
First time since 1998 Tigers are favored over Sooners ... OKLAHOMA 27-24.
No. 20 Nebraska (minus 51â2) at Oklahoma State
Top two offenses in Big 12 ... NEBRASKA 38-24.
Miami (plus 6) at No. 21 Georgia Tech
Yellow Jackets beat 'Canes in Orange Bowl last season ... GEORGIA TECH 24-20.
No. 22 Texas A&M (minus 41â2) at Baylor
Aggies' last five wins have been by six points or fewer ... TEXAS A&M 28-23.
No. 24 Wake Forest (minus 81â2) at North Carolina
Deacons go for first sweep of North Carolina, N.C. State and Duke since '87 ... WAKE FOREST 35-10.
Portland State (no line) at No. 25 Oregon
In three home games, Oregon is averaging 481 yards and 37 points ... OREGON 45-20.
Connecticut (plus 19) at No. 16 Rutgers
Scarlet Knights second in nation in total defense ... RUTGERS 35-14.