Wimbeldon, England ? Andre Agassi grabbed his racket bag and headed for the exit. After a few steps, he stopped and turned around, taking time for one last wave to an adoring crowd, one last look at Centre Court.

One final farewell to Wimbledon.

At least Venus Williams and Andy Roddick know they’ll be back.

Agassi didn’t get the ending he’d hoped for in his last tournament at the All England Club, overwhelmed, 7-6 (5), 6-2, 6-4, in the third round by French Open champion Rafael Nadal, and he even had to share the spotlight on a wild Saturday: Three-time Wimbledon champion Williams and two-time finalist Roddick also lost.

“It’s been a privilege to be out there again for one last time,” Agassi said. “I’ll look back at this as one of my most memorable experiences. To say goodbye, for me, this means as much as winning.”

A few hours later, defending champion Williams bid adieu, too, beaten, 7-6 (8), 4-6, 6-4, by 26th-seeded Jelena Jankovic of Serbia.

Andre Agassi blow a kiss to the crowd. Agassi fell to Rafael Nadal, 7-6 (5), 6-2, 6-4, on Saturday at Wimbledon, England.

And as dusk arrived, No. 3-seeded Roddick joined the procession of stars, losing to Andy Murray of Britain, 7-6 (4), 6-4, 6-4, before a partisan Centre Court crowd.

None of those results is completely stunning. After all, the 36-year-old Agassi has a bad back and was facing, in Nadal, a man ranked No. 2 and 16 years his junior; Williams hasn’t played much this year because of injuries; and Roddick is going through his worst season in quite some time, not reaching any finals.

Still, it all means that at the end of Week 1, only one U.S. man or woman is left in the singles draws: unseeded Shenay Perry, making her first appearance in the fourth round of a Grand Slam tournament. It’s also only the second time since 1922 that zero American men made it to the round of 16 at Wimbledon (2002 was the other).