DURHAM, N.C. ? Stan Gaines knocked down an open jumper on Seton Hall’s first possession for a quick lead on top-ranked Duke.

It was as generous as the Blue Devils’ defense would get Wednesday night.

J.J. Redick scored 18 points, and top-ranked Duke turned in an overwhelming defensive performance to rout Seton Hall, 93-40, in the quarterfinals of the NIT Season Tip-Off.

DeMarcus Nelson added 16 points for the Blue Devils (2-0), who advanced to the tournament semifinals in New York to face the winner of today’s Sam Houston State-Drexel game.

Brian Laing scored 11 points to lead the Pirates (1-1), who missed 22 straight shots to fall behind by 30 at the break and ended up with the second-worst loss in program history. It is the biggest margin of defeat for Seton Hall since a 104-62 loss to Villanova in February 1972 and ranks second only to a 64-point loss to Cincinnati in January 1958.

Duke shot 64 percent, hit 10 of 18 three-pointers and held Seton Hall to just 24-percent shooting, including a 15-minute field-goal drought that turned the game into a dizzying display of Duke’s transition offense and pressure defense.

“It’s just a great feeling,” said Nelson, who hit all six of his shots. “When things are going good like that, you really want to live in the moment.”

The victory made Mike Krzyzewski only the ninth coach to win 650 games at one school.