Paris ? Andy Roddick failed to make it through the opening week at the French Open for the fifth time in as many tries, blowing a two-set advantage Thursday and a fifth-set lead against Argentine Jose Acasuso.

Roddick was broken twice after going ahead 3-1 in the last set and lost, 3-6, 4-6, 6-4, 6-3, 8-6.

“I thought I had the better of him for the better part of three sets,” Roddick said. “Unfortunately, the better part of three sets and three sets is something different.”

Roddick’s career record at Roland Garros fell to 4-5. His best showing was his first appearance in 2001, when he reached the third round.

The quintessential clay-court marathon began in 86-degree sunshine and ended 3 hours, 21 minutes later on a cloudy but muggy evening.

Justine Henin-Hardenne’s latest ailment failed to slow her down. The tournament favorite and 2003 champion required treatment for a back injury that bothered her serve, yet advanced to the third round by beating Virginia Ruano Pascual, 6-1, 6-4.

Henin-Hardenne’s lone loss this year was at Key Biscayne to Maria Sharapova, a potential opponent in the quarterfinals. Sharapova, seeded second, committed just 13 unforced errors and beat 18-year-old Frenchwoman Aravane Rezai 6-3, 6-2. Third-seeded Amelie Mauresmo of France defeated 15-year-old compatriot Alize Cornet, 6-0, 6-2.