La Paz, Bolivia ? Bolivian President Carlos Mesa announced Sunday he would submit his resignation, in a nationally televised speech that came amid growing protests and frustration with his government.

Mesa took office in October 2003, succeeding President Gonzalo Sanchez de Lozada, who resigned in the wake of bloody street protests that took the lives of at least 56 people. Mesa’s government has struggled with a push for greater political autonomy in Bolivia’s most prosperous region.

“Tomorrow, I will submit my resignation to the president of Congress, so Congress can make a decision,” Mesa said in a nationally broadcast address.

In February, he shuffled his cabinet after massive street protests calling for regional autonomy and objecting to a planned increase in the price of fuel oil.

An autonomy drive by Santa Cruz, the nation’s richest province, had earlier forced Mesa to grant concessions clearing the way for provinces to elect their own governors, who are now appointed by the president.

Mesa, a historian and journalist turned politician, said the recent protests by a variety of political and social organizations were “blocking the country.”

Mesa blamed Indian legislator Evo Morales and social leader Abel Mamani of the neighboring city of El Alto for what he called an atmosphere of instability in the Andean nation.

As the president made his emotional address, scores of people gathered in front of the presidential palace to express support for the historian turned politician.

A woman demonstrator, tear in her eyes, told a local television station that she supports mesa “because he’s our president. We do not want to fall in the hands of coca growers, thieves, communists.”

Bolivian supporters of president Carlos Mesa Marisa Vargas, front, and Reinaldo Jiron, background left, shout as the president appears at the balcony of the Presidential Palace in downtown La Paz, Bolivia, on Sunday. The Bolivian president addressed the nation and said he will send a resignation letter to the Congress for approval.

Mesa made clear that a final decision on whether his resignation will be accepted will be made by Bolivia’s Congress.

Whether Congress will accept his resignation remains uncertain. Mesa is an independent without a political party supporting him in congress. If Congress accepts the resignation its president, Sen. Hormando Vaca Diez, would become Mesa’s constitutional successor.