Chicago ? The Chicago White Sox’s biggest inning in five years made Jon Garland the American League’s first 11-game winner.

Juan Uribe and Paul Konerko hit three-run homers, and Frank Thomas added a solo shot in a 10-run sixth inning to lead Chicago to a 12-6 victory over the Arizona Diamondbacks on Wednesday night.

Jermaine Dye also homered for the White Sox (43-22), who overcame a 6-1 deficit to extend the best record in the major leagues.

Despite a subpar performance, Garland improved to 11-2.

“I probably shouldn’t have but it worked out to my advantage,” he said. “The guys came up big with the bats, and they were hitting the ball well.”

Especially in the sixth when the White Sox sent 13 hitters to the plate in their biggest inning since April 18, 2000, when they scored 11 runs against Seattle.

“It kind of (happened) out of nowhere,” Konerko said. “We weren’t really doing too much with the bats the last couple of days, but I really don’t know where it was other than we just busted out. We hadn’t really had an inning like that all year, so it came at the right time.”

Garland gave up six earned runs and six hits in six innings. He struck out four and walked three. He lasted just long enough to take advantage of the big inning.

“Early this year when I have been missing, I have been missing away from the plate. Today, I missed over the plate with a lot of stuff. They got me,” said Garland, who gave up a season-high three home runs.

Tony Clark hit a three-run homer, and Kelly Stinnett and Chad Tracy added solo shots for Arizona, which couldn’t complete the three-game sweep.

“We’ve got to finish it out, we didn’t. We gave up a big inning. Ten runs is a big inning,” Diamondbacks manager Bob Melvin said.

Trailing 6-1, the White Sox got one run in the fifth on a two-out double by Joe Crede and an error by third baseman Troy Glaus. In the sixth, the White Sox hit the three homers and scored 10 runs to take a 12-6 lead. Thomas homered off starter Russ Ortiz (4-6) with one out in the sixth, his fourth in just 21 at-bats since returning from a foot injury.

Nationals 1, Angels 0

Anaheim, Calif. – Texas castoff Ryan Drese made a sensational debut for Washington, holding Los Angeles to two hits over eight inning. Brian Schneider homered off Bartolo Colon in the sixth inning, giving the Nationals two wins in their three-game series matching NL East and AL West division leaders.

Chicago's Frank Thomas (35) pats Paul Konerko on the head after Konerko hit a three-run home run during a 10-run sixth inning. The White Sox defeated Arizona, 12-6, Wednesday night in Chicago.

Reliever Chad Cordero worked out of his own bases-loaded, no-out situation in the ninth for his 18th consecutive save and 21st in 23 chances.

Red Sox 6, Reds 1

Boston – Bronson Arroyo gave the Red Sox their fourth straight strong performance by a starter, and David Ortiz drove in three runs to lead Boston to a sweep of Cincinnati. Boston took the three-game series by a combined score of 23-4 and outhit Cincinnati 36-15. The Reds, who managed just one hit in a 7-0 loss Tuesday night, broke a 16-inning scoreless stretch when Ken Griffey Jr. came in on a wild pitch in the seventh.

Orioles 5, Astros 1

Baltimore – Rodrigo Lopez pitched eight innings of four-hit ball, and Baltimore beat Houston for a three-game sweep. Melvin Mora homered, Jay Gibbons had three hits, and Brian Roberts went 2-for-3 with two RBIs for the Orioles, who outscored Houston 19-7 in their first interleague sweep since July 1999, against Montreal.

Lopez (6-2) allowed one run, struck out seven and walked one in winning his fourth straight decision. He’s 4-1 in 10 starts since April 21.

Devil Rays 5, Brewers 3

St. Petersburg, Fla. – Hideo Nomo allowed two runs in seven innings for his 200th combined major-league and Japanese victory, leading Tampa Bay over Milwaukee.

The win qualified Nomo (4-6) for the Meikyukai, one of two special honors for Japanese players. Membership is automatic after a player reaches 2,000 hits or 200 wins. He is the 16th pitcher and 45th member overall. The other top honor is the Japanese Hall of Fame, where members are elected.

Blue Jays 5, Cardinals 2

Toronto – Ted Lilly pitched seven scoreless innings to lead Toronto over St. Louis. Facing the Cardinals for the first time, Lilly (4-7) allowed just four singles and lowered his ERA to 6.48. He had lost his three previous starts. The 28-year-old left-hander struck out six and walked three for his first win since May 25 versus Boston.

Indians 7, Rockies 6, 11 innings

Cleveland – Aaron Boone finally did something to get Cleveland fans off his back. Stuck in a season-long slump, Boone homered leading off the 11th inning, and the Indians rallied for a victory over Colorado to extend their winning streak to a season-high five games.

Tigers 8, Padres 2

Detroit – Placido Polanco had three hits and three RBIs, and Detroit ended Adam Eaton’s eight-game winning streak with a victory over San Diego. Craig Monroe also had three hits – falling a triple short of the cycle – and scored three times for the Tigers.

Yankees 7, Pirates 5, 10 innings

New York – Jason Giambi hit a two-run homer into the upper deck in the 10th inning, and New York rallied past the Pittsburgh. Jorge Posada tied the game with a two-out double off Jose Mesa in the ninth, and New York overcame Kevin Brown’s latest back injury to beat Pittsburgh for the second consecutive night.

Giants 8, Twins 4

Minneapolis – Michael Tucker doubled and drove in three runs, and Moises Alou went 4-for-4 to lead San Francisco over Minnesota. Noah Lowry (3-6) tied a season high with seven strikeouts after being staked to a 4-0 lead after the first inning, helping the Giants snap a four-game losing streak and win for just the third time in the last 18 games. The Giants jumped on Twins starter Kyle Lohse (5-5) early.

Athletics 3, Mets 2

Oakland, Calif. – Marco Scutaro lined a game-winning single off the wall in left-center with two outs in the ninth, lifting Oakland over New York. Justin Duchscherer (3-1) pitched two innings for the win as the A’s won their third straight and eighth game in June to surpass their entire May win total of seven.

Rangers 9, Braves 5

Arlington, Texas – Chan Ho Park won his sixth straight decision despite struggling against Atlanta. Alfonso Soriano and Kevin Mench both had two-run doubles in the Rangers’ five-run first inning, when the first six batters reached against Braves rookie Kyle Davies (2-2).

Mariners 5, Phillies 1

Seattle – Ichiro Suzuki hit a leadoff homer, and Aaron Sele made it stand up with six solid innings in his sixth straight strong start, leading Seattle over Philadelphia. Mike Morse hit his first major-league home run, a two-run shot, and Randy Winn also connected.