Paris ? Venus Williams can brag that she lasted longer than her sister at the French Open — by 28 minutes.

Williams again came up short in a bid for her first Grand Slam title since 2001, losing to Anastasia Myskina, 6-3, 6-4, Tuesday in the Roland Garros quarterfinals.

The upset came less than half an hour after Jennifer Capriati eliminated Serena Williams, 6-3, 2-6, 6-3.

Because the sisters lost in the same round of a tournament for the first time, it will be 2001 champion Capriati against Myskina in the semifinals Thursday, instead of Williams vs. Williams.

“We’re going to pack our bags and leave,” Venus said. “There’s nothing left for us here anymore.”

The double blow to family pride came on a drab, drizzly day in the surprise-filled event.

“I’m alive. I’m breathing. I’m healthy. Things could be worse,” Serena said. “But, I mean, obviously I’m not happy.”

It’s the first time since the 2001 French Open that both sisters lost at a major event before the semifinals, fitting a pattern of surprises in this year’s tournament. Andre Agassi was beaten by a qualifier ranked 271st, while top-ranked Roger Federer and defending champions Justine Henin-Hardenne and Juan Carlos Ferrero also lost in the opening week.

Capriati now has beaten Williams twice in a month after losing the previous eight meetings in their rivalry.

Serena Williams of the United States reacts as she plays against compatriot Jennifer Capriati in their quarterfinal match. Capriati won, 6-3, 2-6, 6-3, Tuesday in Paris.

Joining Capriati in the final four were two Russians, Myskina and Elena Dementieva, and Paola Suarez of Argentina.

At 27, Suarez is a first-time Grand Slam semifinalist. So is the 22-year-old Myskina, at No. 6 the highest-seeded woman left in the draw. She played conservatively while waiting for Venus Williams to misfire, and the tactic worked, with Myskina winning 69 points, 43 on Williams errors.

The No. 4-seeded Williams blamed rustiness after being sidelined by an ankle injury three weeks ago.

“I didn’t have the preparation that I wanted, which is tough because you need to be physically ready to run, and you need to be consistent,” she said.

Her No. 2-seeded sister, sidelined for eight months after surgery on her left knee Aug. 1, appeared to favor that leg at times against Capriati. In the final set, she bent over following one errant shot, winced after another and declined to chase a Capriati drop shot that went for a winner.