Louisville, Ky. ? Louisville coach Rick Pitino said he felt fine Saturday — until Marquette’s Steve Novak started hitting three-pointers.

Novak made eight three-pointers and scored a career-high 30 points as Marquette beat No. 4 Louisville, 77-70, in Pitino’s first game back from a two-day medical leave.

“Except for Novak’s shooting, I feel fine. I don’t feel good about our basketball team. That would make anybody sick,” Pitino said.

Travis Diener added 17 points and seven assists as the Golden Eagles (13-5, 4-3 Conference USA) snapped No. 4 Louisville’s 16-game winning streak. Novak, who went 9-for-16 from the field and 4-for-4 from the free-throw line, also had eight rebounds

“I can’t remember but a couple of games in high school like this. None in a place like this,” said Novak, a sophomore from Brown Deer, Wis.

Marquette also ended Louisville’s 16-game winning streak at Freedom Hall, which dated to the Golden Eagles’ 78-73 victory here Feb. 27. Marquette trailed by 19 in that game, and coach Tom Crean showed his players tape of the comeback Friday.

“It was very important that we remembered we could win here,” said Crean, who has won five of six games against Louisville since Pitino became the Cardinals’ coach in 2001.

Luke Whitehead had 14 points and a career-high 19 rebounds for Louisville (16-2, 6-1), which shot a season-low 33 percent (21-for-64) and went 5-for-34 from three-point range (15 percent). The Cardinals mustered a season-low eight assists and shot worse than 40 percent for the third straight game.

“Marquette taught us a difficult lesson,” Pitino said. “I haven’t been pleased in about a week and half with our practices. We haven’t passed the ball well.”

No. 1 Duke 82, No. 15 Georgia Tech 74

Atlanta — Luol Deng scored a career-high 22 points, and Duke extended its winning streak to 15 games. Georgia Tech hasn’t beaten the Blue Devils since 1996.

Duke (18-1, 7-0 Atlantic Coast Conference) went ahead for good on Deng’s free throw with 3:13 remaining, and J.J. Redick followed with a three-pointer that pushed the margin to 72-68.

B.J. Elder made a couple of free throws with 2:52 left to get Georgia Tech (16-4, 4-3) within a basket, but the Yellow Jackets missed their next five shots.

No. 2 Stanford 83, Oregon 80

Eugene, Ore. — Chris Hernandez scored all of his 22 points in the second half and led Stanford back from a 19-point deficit to stay undefeated. Stanford (18-0, 9-0 Pac-10) remains one of just two undefeated Division One teams in the nation.

No. 3 Saint Joseph’s 83, Temple 71

Philadelphia — Jameer Nelson and Delonte West each had 21 points, and Saint Joseph’s set an Atlantic 10 record with 20 three-pointers to remain unbeaten. Pat Carroll scored 20, and Chet Stachitas added 12 for the Hawks (18-0, 8-0), who extended their school-record winning streak to 18.

Vanderbilt 66, No. 5 Kentucky 60

Nashville, Tenn. — Dan Cage hit a three-pointer with 2:18 left that gave Vanderbilt the lead for good, and the Commodores held on. Kentucky (14-3, 4-2 Southeastern Conference) had its 10-game road winning streak in the SEC snapped. The last time the Wildcats lost away from Rupp Arena in the SEC was Feb. 27, 2002 — in Memorial Gym to Vanderbilt. Vanderbilt (14-4, 3-4) needed this victory desperately after having lost four of its previous five, a skid that dropped the Commodores out of the Top 25 earlier this week.

No. 6 Connecticut 63, Boston College 58

Boston — Emeka Okafor and Rashad Anderson scored 16 points each, and Connecticut held off Boston College in the last three minutes. Connecticut (17-3, 5-1 Big East) trailed 30-29 at halftime, but never was behind after Ben Gordon’s two free throws made it 47-44. Boston College (13-7, 2-5) tied the game three times after that.

Charlotte 86, No. 8 Cincinnati 83

Cincinnati — Curtis Withers made a pair of free throws with 45 seconds left to seal Charlotte’s first victory in 10 tries in Cincinnati. Brendan Plavich finished with 17 points for Charlotte (13-5, 5-2 CUSA).

No. 9 Arizona 61, Washington State 57

Pullman, Wash. — Channing Frye hit a short jumper with 58 seconds left to help Arizona pull out the win. Frye scored 17 points as Arizona (14-4, 6-3 Pac-10) won its 37th straight over Washington State.

No. 11 Miss. State 73, Auburn 68

Auburn, Ala. — Shane Power hit four free throws in the final 19 seconds, and Mississippi State (18-1, 7-1 Southeastern Conference) won for its best league start in 41 years.

Clemson 81, No. 12 North Carolina 72

Clemson, S.C. — Shawan Robinson scored a career-high 24 points to lift Clemson. The win was the biggest for Clemson (9-10, 2-6 Atlantic Coast Conference) since defeating then-No. 1 North Carolina, 75-65, in February 2001. North Carolina (13-5, 3-4) has yet to win a conference road game this season. Rashad McCants led the Tar Heels with 26 points.

No. 19 Wake Forest 91, Virginia 78

Winston-Salem, N.C. — Justin Gray scored 26 points in a nearly flawless shooting performance to lead Wake Forest (13-4, 4-3 ACC).

No. 20 Syracuse 76, Virginia Tech 64

Syracuse, N.Y. — Gerry McNamara scored 26 points, and Hakim Warrick had 15 points and seven assists to lead No. 20 Syracuse (14-3, 4-2 Big East), which had lost two straight, including an embarrassing 66-45 setback at home last week to No. 7 Pittsburgh. Virginia Tech (8-10, 1-6 Big East) lost its fifth straight.

Ohio State 65, No. 21 Purdue 59

West Lafayette, Ind. — Terence Dials dunked over Ivan Kartelo and converted the three-point play in the final minutes to lead Ohio State (10-10, 2-5 Big Ten).

Tennessee 65, No. 22 Florida 63

Knoxville, Tenn. — Scooter McFadgon scored 24 points, and Brandon Crump added 11 points and 11 rebounds to help Tennessee (11-6, 3-4 Southeastern Conference)rally in the final minutes.

Mississippi 79, No. 24 S. Carolina 68

Oxford, Miss. — Justin Reed scored a career-high 32 points and had 11 rebounds to lift Mississippi. Reed was 10-of-19 from the field and 11-of-11 from the free-throw line for the Rebels (11-7, 3-4 SEC), who are unbeaten in seven meetings with South Carolina.