St. Louis ? Downtrodden Saint Louis came up with a victory to hang its season on.

Marque Perry scored five of his 25 points in the final 13 seconds and maneuvered inside for the game-winning layup with 3.2 seconds to go as Saint Louis upended second-ranked Louisville, 59-58, Wednesday night.

“It’s so big I can’t really explain it,” Perry said. “Coach told us if we’re real close at the end, you never know what can happen.”

The Billikens (9-12, 3-7) were coming off a pair of road losses to middle-of-the-road Conference USA teams, making them an unlikely team to put an end to the nation’s longest winning streak. They entered the game last in the conference’s American Division and in danger of not even making the postseason tournament.

“I would have been happy to beat Hazelwood Central (High) tonight, because we really needed a win,” coach Brad Soderberg said. “I’ll go on record and say we outworked them.”

This was Saint Louis’ biggest win since a victory over top-ranked Cincinnati in the first round of the Conference USA tournament in 2000, and the school did it despite 34 percent shooting, compensating by forcing 16 turnovers.

Louisville (18-2, 8-1 C-USA) had won 17 in a row since a two-point loss to Purdue in the second game of the season Nov. 30, and coach Rick Pitino said the Cardinals’ 14-for-20 showing at the free-throw line was the difference.

“They played a terrific game and stopped a streak we had a lot of fun with,” Pitino said. “Now it’s time to start a new streak.”

Saint Louis' Marque Perry, center, celebrates with teammates Kenny Brown (41) and Drew Diener (21). Perry scored the game-winning layup with 3.2 seconds left in the Billikens' 59-58 victory Wednesday over No. 2 Louisville in St. Louis.

No. 4 Florida 74, Mississippi 55

Gainesville, Fla. — Danish superstar Christian Drejer played his best game of the season, finishing with 11 points and five assists, as Florida turned a two-point game into a blowout. Florida (20-3, 9-1 Southeastern Conference) reached the 20-win mark for the fifth straight season. The Rebels (12-9, 3-7) lost their fifth straight.

No. 7 Pittsburgh 82, West Virginia 46

Pittsburgh — Donatas Zavackas came out of a shooting slump with 15 points and Pittsburgh finally played a runaway game after a succession of close ones. The Panthers (17-3, 7-2 Big East) fell from No. 2 to No. 7 in the AP poll while dropping road games against Syracuse and Notre Dame, but they never were challenged by the smaller and less physical Mountaineers (12-9, 3-6).

No. 11 Marquette 73, DePaul 60

Rosemont, Ill. — Steve Novak scored a career-high 17 points, including four straight three-pointers during a decisive second-half stretch, as Marquette beat DePaul. Novak finished with five three-pointers, topping his career high by two. Chicago native Dwyane Wade added 17 points, eight assists, seven rebounds and three steals for the Golden Eagles (18-3, 9-1 Conference USA), who won their 10th straight.

No. 12 Creighton 70, SW Missouri St. 67, OT

Omaha, Neb. — Brody Deren’s inside basket gave Creighton the lead and then Michael Lindeman made two free throws with 2.3 seconds left as the Bluejays came back from a 15-point deficit. Creighton (22-2, 12-1 Missouri Valley Conference) won its 14th straight home game, despite playing the extra period without leading scorer Kyle Korver, who fouled out in the final minute of regulation after keying the Bluejays’ comeback.

No. 16 Maryland 74, Florida State 72

Tallahassee, Fla. — Steve Blake scored Maryland’s final seven points, including four free throws in the final 17.5 seconds, as the Terrapins rebounded from two straight losses. Florida State (11-10, 2-8 Atlantic Coast Conference) got within a point at 70-69 on Todd Galloway’s layup with 17.5 seconds left before Blake’s free throws. Drew Nicholas scored 20 points for Maryland (15-6, 7-3). Trevor Harvey led Florida State with a career-high 19 points and a game-high 10 rebounds.