Indianapolis ? Peyton Manning showed he was ready for the playoffs Sunday.

The Indianapolis Colts now have two weeks to fine-tune their explosive offense.

Manning threw for 290 yards and five touchdowns, Edgerrin James ran for 126 yards, and the defense manhandled Michael Vick in a 38-7 win over Atlanta to clinch a playoff spot.

“That was the goal coming in here, to get into the playoffs,” Manning said. “We need to keep it going the next two weeks.”

The Colts (11-3) couldn’t have asked for more from Manning, who now has led Indianapolis to four playoff appearances in five years but has been dogged by an 0-3 postseason record.

With Tennessee’s 28-26 win Sunday over Buffalo, the Colts will have to wait another week for a chance to clinch their first division title since 1999. One more win — or a Titans loss — gives Indianapolis the AFC South title.

Manning completed 25 of 30 passes, became the first Colts quarterback to throw for five TDs in a game twice in a season and the first NFL player to achieve that since Buffalo’s Jim Kelly in 1991.

Manning also broke the NFL record for most consecutive seasons with 25 touchdown passes (six). The record of five was set by Miami’s Dan Marino in the 1980s and was tied by Green Bay’s Brett Favre in the 1990s.

“I’m starting to get numb to those,” coach Tony Dungy said. “He was very sharp all week in practice, and he’s been very, very hot the last month or so.”

Indianapolis quarterback Peyton Manning (18) and Atlanta quarterback Michael Vick meet in the middle of the field following the Colts' 38-7 win. Manning threw for 290 yards and five touchdowns while Vick was sacked four times and committed two turnovers Sunday in Indianapolis.

Atlanta (3-11) looked like a team reeling from a midweek coaching change.

Vick was just 2-of-12 for 25 yards with a passer rating of 4.9 in the first half when the Falcons were outgained 302-28. He finished 6-of-19 for 47 yards with four carries for 30 yards.

“It’s the worst game I ever had,” Vick said. “Why? I don’t know.”

James and wide receiver Marvin Harrison each topped the 100-yard mark in the first half.

Panthers 20, Cardinals 17

Tempe, Ariz. — John Kasay kicked a 49-yard field goal with four seconds to play to give the Panthers the win and the NFC South title. In clinching its second division title and first playoff berth since 1996, Carolina (9-5) snapped a three-game losing streak. Eight of the Panthers’ victories have come in the final two minutes or in overtime. Carolina tied an NFL record with its seventh win by three points or less this season. The Cardinals did it in 1998.

Rams 27, Seahawks 22

St. Louis — The Rams clinched the NFC West title as Marshall Faulk led a final, clock-killing march. It was the third West title in five years for the Rams (11-3), who had to escape a desperation drive by Seattle (8-6). It also was the 13th straight home win for St. Louis, tying a franchise record set from 1998-2000.

Saints 45, Giants 7

New Orleans — Joe Horn had four touchdown catches, and Aaron Brooks threw for five scores. Horn scored on receptions of 50, 13, 7 and 18 yards, and set a team record for TD receptions. The victory kept the Saints’ slim playoff hopes alive at 7-7. It was the sixth straight defeat for the Giants (4-10).

Bears 13, Vikings 10

Chicago — Rex Grossman won in his NFL first start at quarterback. Another rookie, Charles Tillman, intercepted Daunte Culpepper with 1:02 left to preserve the victory. Minnesota (8-6) lost a chance to move closer to the NFC North title. Culpepper drove the Vikings from their 81 to the Chicago eight in the closing minutes before Tillman’s interception.

Packers 38, Chargers 21

San Diego — Brett Favre threw a season-high four touchdown passes to lead the Packers. Combined with Minnesota’s loss, it left the Packers tied with the Vikings in the NFC North at 8-6. Three of Favre’s TDs came in the fourth quarter after San Diego (3-11) had taken a 21-17 lead.

Titans 28, Bills 26

Nashville, Tenn. — Backup quarterback Billy Volek, playing in place of Steve McNair, threw for two touchdowns and ran for another in his first NFL start. Drew Bledsoe drove the Bills (6-8) 81 yards in nine plays and threw a six-yard TD pass to Mark Campbell with 24 seconds left. But Bobby Shaw couldn’t control a low pass on the two-point conversion try.

Bengals 41, 49ers 38

Cincinnati — Chad Johnson caught the first of Jon Kitna’s two touchdown passes, and Rudi Johnson ran for 174 yards and two scores as the Bengals stayed in playoff contention, and the 49ers remained winless on the road.

Raiders 20, Ravens 12

Oakland, Calif. — The Raiders shut down Jamal Lewis and the Ravens’ offense to snap Baltimore’s three-game winning streak. The loss dropped Baltimore (8-6) into a tie with Cincinnati for first in the AFC North.

Patriots 27, Jaguars 13

Foxboro, Mass. — New England won its 10th straight as Tom Brady threw for two touchdowns. However, Byron Leftwich’s 27-yard TD pass to Kevin Johnson with 3:22 left gave the Jaguars (4-10) the first touchdown scored against the Patriots (12-2) in Foxboro in five games.

Broncos 23, Browns 20, OT

Denver — Jason Elam kicked a 36-yard field goal with six seconds left in regulation, then a 25-yarder in overtime, as the Broncos kept the lead for the final AFC playoff spot. Denver (9-5) has won three straight and four of five. Running back Clinton Portis, who had 139 yards and two touchdowns, had to be helped off the field after injuring his right leg the play before Elam’s winning kick.

Cowboys 27, Redskins 0

Landover, Md. — Rookie Terence Newman tied a team record with three interceptions, and Troy Hambrick ran for a career-high 189 yards for Dallas. It was the first shutout in the Cowboys-Redskins rivalry in 32 years.

Buccaneers 16, Texans 3

Tampa, Fla. — The Bucs got back to .500 for the first time in six weeks and remained in contention for an NFC wild-card berth as Thomas Jones ran for 134 yards and a touchdown.

Jets 6, Steelers 0

East Rutherford, N.J. — Curtis Martin ran for 174 yards and went over the 1,000-yard mark for the ninth straight season as the Jets (6-8) won in the snow on Doug Brien’s two field goals. Martin joined Barry Sanders as the only players in NFL history to accomplish the feat. Sanders had 10 straight 1,000-yard seasons.