New York The U.S. Open title will stay in the Williams family.
Serena and older sister Venus won their semifinals Friday, setting up their third straight meeting in a Grand Slam final.
Serena, the 1999 Open winner, beat Lindsay Davenport, 6-3, 7-5, after Venus, who won the tournament the last two years, beat Amelie Mauresmo, 6-3, 5-7, 6-4.
"Venus is playing well and I'm playing all right," Serena said with a wide smile. "I'm playing well, too."
Down 5-2 in the second set, top-seeded Serena won her last five games against Davenport and took nine of the last 10 points. Serena had 13 aces to just three for Davenport.
The harder-serving Venus had only three aces, the same as Mauresmo. And she had 10 double faults to four for the 10th-seeded Frenchwoman.
Venus, who suffered from a blister on her right hand, also had more unforced errors 44-35.
"It was hard to hold the racket at times, but you only get one chance at the final and you try to take it," Venus said.
Pete Sampras should be favored in the semifinals against No. 24 Sjeng Schalken. Lleyton Hewitt and sixth-seeded Andre Agassi meet in the other men's semifinal.