Chris Brown is running over defenders, and that could mean trouble for No. 2 Oklahoma.

After a slow start, Brown leads the nation in rushing with 1,303 yards, and he’s helped Colorado win five straight and rise to No. 13 entering Saturday’s game against the undefeated Sooners.

Oklahoma may be favored by 10 points, but the Sooners haven’t beaten the Buffaloes since 1988, going 0-8-1 in that span. Then again, the teams didn’t play each other the past two years.

“I think it’s fair to assume that we’re a little bit different team right now,” Sooners fourth-year coach Bob Stoops said.

Colorado (6-2, 4-0 Big 12 Conference) won the last meeting, 38-24 in 1999 Stoops’ first season in Norman.

The 6-foot-3, 220-pound Brown has been the driving force behind Colorado’s rise to the top of the Big 12 North, averaging nearly 200 yards a game during the winning streak. Ever since the Buffs went through a quarterback change earlier this season freshman Robert Hodge for departed Craig Ochs Brown has regained the form that carried Colorado to the Big 12 title last season.

“We have great respect for their team, for what they did last year and the way they’re playing right now,” Stoops said. “We recognize it as another big challenge.”

The Sooners (7-0, 3-0), who lead the Big 12 South, counter with the nation’s second-ranked defense, which allows 13.1 points and 252.2 yards a game.

“They obviously create an extreme challenge for our offense,” Colorado coach Gary Barnett said. “We are probably much more predictable and traditional than anybody they have played.”

The picks:

No. 1 Miami (minus 39) at Rutgers

Don’t watch … MIAMI, 52-0.

No. 13 Colorado (plus 12) at No. 2 Oklahoma

Sooners’ defense loves a challenge … OKLAHOMA, 28-14.

Pittsburgh (plus 13) at No. 3 Virginia Tech

Pitt can shackle Tech’s untouchables Suggs & Jones … PITTSBURGH, 24-21.

Boston College (plus 10) at No. 4 Notre Dame

Irish haven’t forgotten ’93 loss to BC … NOTRE DAME, 31-17.

No. 5 Georgia (minus 2) vs. Florida (at Jacksonville, Fla.)

‘Dawgs have rare chance to beat up on Gators … GEORGIA, 31-23.

No. 23 Minnesota (plus 12 1/2) at No. 6 Ohio State

Gophers facing first Top 25 team this season … OHIO STATE, 37-14.

No. 7 Texas (minus 4) at Nebraska

Longhorns’ Brown only visiting coach since ’91 to win in Lincoln … TEXAS, 31-21.

No. 16 Arizona State (plus 7 1/2) at No. 8 Washington State

Cougs save QB Gesser from ASU’s DE Suggs … WASHINGTON STATE, 34-30.

Wisconsin (plus 9) at No. 9 Iowa

Hawkeyes tough even without leading RB Russell … IOWA, 24-13.

Georgia Tech (plus 10) at No. 10 North Carolina State

Wolfpack shooting for best-ever 10-0 … NC STATE, 34-21.

Vanderbilt (plus 22) at No. 12 Alabama

‘Bama best team in nation on probation … ALABAMA, 42-7.

No. 14 Kansas State (minus 31) at Kansas

Wildcats make it 10th straight against Jayhawks … KANSAS STATE, 45-7.

Michigan State (plus 15) at No. 15 Michigan

Spartans won last year with a second left … MICHIGAN, 28-20.

No. 18 Florida State (minus 10 1/2) at Wake Forest

‘Noles bench QB Rix, hope to stay in Top 25 … FLORIDA STATE, 31-17.

Stanford (plus 13) at No. 19 Oregon

In ’01, Cardinal ended Ducks’ home win streak at 23 … OREGON, 35-20.

Illinois (plus 14) at No. 20 Penn State

Lions schedule takes an easy turn … PENN STATE, 35-14.

No. 21 Bowling Green (minus 18) at Kent State

Falcons have 10-game winning streak … BOWLING GREEN, 47-17.

Missouri (plus 10) at No. 22 Iowa State

Cyclones better not think this will be a breeze … IOWA STATE, 28-21.

No. 24 Colorado State (minus 1) at Air Force (today)

Falcons falling apart after 6-0 start? … COLORADO STATE, 28-21.

No. 25 Tennessee (minus 1 1/2) at South Carolina

Gamecocks out to end nine-game slide vs. Vols … SOUTH CAROLINA, 24-21.