Kansas City, Mo ? Even his teammates are curious as to what Priest Holmes will do next.

Arizona, which takes a five-game losing streak into Arrowhead Stadium on Sunday, ranks among the bottom of the NFL in most defensive categories.

And so did Seattle, which gave up more than 300 yards rushing and receiving to Holmes last week in a game the Chiefs wound up losing 39-32.

“He should be (league MVP),” said Chiefs center Casey Wiegmann. “He’s unbelievable. He means more to this team than anything, not only offensively but defensively.

“He’s special,” Wiegmann added. “All it takes is a little gap to get him going and get him out in the open field. He’s done a great job of that.”

Once again in the lead in the NFL rushing race, Holmes will be going against a Cardinal defense ranked 27th against the run, with an average yield of more than 131 yards per game.

“They’ve got a big, huge front four and their linebackers are fast,” said Wiegmann. “Their front four guys take up a lot of space and let their linebackers make the tackles. We’ve got to stay on them.”

Will Shields, the Chiefs’ Pro Bowl right guard, figures Holmes’ feats are even more impressive because everybody on the other team knows he’s going to carry the brunt of the offense.

Kansas City running back Priest Holmes (31) bolts for a 14-yard run in the Chiefs' 39-32 loss to Seattle on Sunday.

“You have to be prepared when he does get his touches and get him the open space and push it along,” Shields said. “Everybody’s going to stack the line. They know that sooner or later he’s going to get the ball one way or another.”

Before Holmes emerged last year to lead the NFL with 1,555 yards rushing, the Chiefs’ main weapon was tight end Tony Gonzalez.

Ironically, Gonzalez was one reason Holmes decided to take the Chiefs’ offer when he left Baltimore after the 2000 season.

“I thought having Tony here would give me a little less attention in the backfield, enable me to do some more things,” Holmes said.

But the two have combined to give the Chiefs a rare one-two offensive punch.

“That’s what makes us unique now,” said Shields. “That’s why we’re becoming a full operational offense, one that can run it and throw it and do different things.”