New York ? Mo Vaughn made up for a season’s worth of struggles with one dramatic swing.

Vaughn hit a three-run homer in the eighth inning to give him 1,001 RBIs and lift the New York Mets to a 3-2 victory over the Yankees on Sunday night.

David Wells delivers a pitch in the Yankees' 3-2 loss to the Mets on Sunday at Shea Stadium.

“This is the way I envisioned things,” Vaughn said. “It hasn’t happened very much, but this whole team has been very positive with me.”

The Mets took two of three from their crosstown rivals, only the second time they’ve won a series against the Bronx Bombers in nine tries since interleague play began in 1997.

That doesn’t include the 2000 World Series, won by the Yankees in five games.

Roberto Alomar led off the eighth with a soft double that fell in front of diving left fielder Rondell White, and first baseman Jason Giambi booted Mike Piazza’s grounder for an error to put runners at the corners.

“It tailed away from me,” White said. “I should have had it.”

After coming over in a trade from Anaheim last winter, Vaughn stepped to the plate with just four home runs and 21 RBIs this season.

He’s been booed relentlessly by Mets fans lately, but he sent Shea Stadium into a frenzy by driving an 0-1 pitch from David Wells (7-4) into the right-field bullpen for a 3-2 lead.

With Mets fans cheering and waiting for Vaughn to come out of the dugout for a curtain call, Timo Perez emerged for a moment with a smile instead.

“I’m a pretty confident person, but when you do something on this type of stage, it puts a smile on your face,” Vaughn said.

Big Mo is batting .455 (30-for-66) lifetime with nine home runs against Wells the most for any active hitter against any active pitcher.

“That’s the one guy in their lineup I know can really burn me. He’s probably the best player I’ve ever seen in my career because he owns (me),” Wells said. “I don’t fear him. I’m going to go after him and challenge him until I get his number, because he’s certainly got mine.”

Mark Guthrie (1-0) escaped a jam in the eighth, striking out Bernie Williams with two on and getting Robin Ventura to ground into an inning-ending double play.

“Hopefully, we can keep this intensity up for the rest of the year,” Guthrie said. “That’s what the Yankees do every night for years, that’s what the Braves do every night for years. It’s what makes the champions every year, and we’ve got a taste of it now.”

Armando Benitez, who blew a ninth-inning lead Friday, pitched a perfect ninth for his 15th save in 17 chances.

“We stole one from them, they stole one from us,” said Yankees shortstop Derek Jeter.

Red Sox 6, Braves 1

Atlanta Derek Lowe outpitched Tom Glavine and became the first AL pitcher to win 11 games, helping the Boston Red Sox beat the Atlanta Braves 6-1 Sunday.

Jason Varitek and Trot Nixon homered for the Red Sox.

Lowe (11-2) allowed seven hits in seven innings, including four which didn’t leave the infield.

Lowe struck out a career-high 10 and hit one batter. He also rapped his first career hit, a third-inning single up the middle off Glavine (11-3).

Glavine had his shortest outing of the season. He gave up seven hits and five runs three earned.

Orioles 4, Phillies 2

Philadelphia Travis Driskill, a 30-year-old rookie, won his fourth straight decision as Baltimore beat Philadelphia.

Driskill (4-0) pitched 61/3 innings, allowing two runs on five hits. He walked two and struck out five.

Jorge Julio pitched the ninth for his 13th save in 17 chances.

Philadelphia starter Terry Adams (3-5) pitched a season-high seven innings, but walked Driskill with two out in the third.

Brian Roberts and Melvin Mora followed with a pair of RBI doubles.

Expos 6, Blue Jays 5

Montreal Mike Mordecai hit a game-winning RBI single with one out in the ninth inning to give Montreal their fifth straight win.

Mordecai, who entered the game as a defensive replacement in the eighth, singled off Kelvim Escobar (3-3) to drive Troy O’Leary home with the winning run.

Scott Stewart (3-1) got Carlos Delgado the only batter he faced to ground to second with the go-ahead run on third to end the ninth.

Twins 7, Brewers 6

Milwaukee David Ortiz drove in three runs in a four-run first inning, and Dustan Mohr, Denny Hocking and Corey Koskie hit solo home runs, leading Minnesota over Milwaukee.

Koskie’s home run in the seventh inning off Nelson Figueroa (1-5) broke a 6-all tie and gave reliever Tony Fiore (5-1) the win.

Eddie Guardado pitched the ninth for his AL-leading 20th save in 22 chances.

White Sox 10, Cubs 7

Chicago Carlos Lee drove in a career-high seven runs with a grand slam and a three-run homer, leading the Chicago White Sox over the Cubs, avoiding a sweep by their crosstown rivals.

Kerry Wood (6-5), who turned 25 Sunday, had one of his worst outings, allowing a career-high eight runs in four-plus innings.

Antonio Osuna pitched the ninth for his third save.

Indians 5, Rockies 4

Denver Bartolo Colon won for the fourth time in five starts, and John McDonald drove in two runs to lead Cleveland over Colorado.

McDonald put the Indians up 4-1 in the seventh inning with a two-run double off Colorado starter Denny Neagle (4-4). He also scored on a single by Jolbert Cabrera in the third.

Astros 7, Rangers 6

Houston Craig Biggio hit an RBI single off John Rocker in the ninth to give Houston the victory over Texas.

Julio Lugo hit two home runs for the Astros, who gave up a two-run lead in the ninth when Billy Wagner blew his second save of the season.

It was another rough outing for Rocker (1-2), who was called up from the minors a week ago.

Devil Rays 4, Marlins 1

Miami Luis Castillo extended his hitting streak to 31 games, matching the longest in the major leagues since 1987, but Tampa Bay scored four times in the final two innings to beat Florida.

Castillo singled leading off the first inning to tie for the fifth-longest streak in the National League since 1900.

The Devil Rays went 172/3 innings without a run until Steve Cox lined a two-out RBI single in the eighth.

Athletics 2, Giants 1

San Francisco Barry Zito pitched into the seventh inning for his eighth straight victory, and Adam Piatt drove in the go-ahead run as Oakland won the Bay Bridge series, beating San Francisco.

Oakland took two of three on the weekend from its cross-bay rival with another outstanding performance from Zito (9-2), who gave up four hits and struck out five in 6 2-3 innings.

Billy Koch pitched the ninth for his 15th save.

Dodgers 5, Angels 4

Los Angeles Eric Karros and Marquis Grissom hit back-to-back homers in the sixth inning and Mark Grudzielanek hit a tiebreaking single in the seventh as Los Angeles beat Anaheim Angels to win the Freeway Series.

After Grudzielanek’s hit off Al Levine (3-2) broke a 4-all tie, Dennis Cook came in and hit Shawn Green with a pitch in the ribs, causing the benches to clear.

D-Backs 11, Tigers 2

Phoenix Mark Grace drove in three runs with a homer and his 500th career double as Arizona beat Detroit.

Rick Helling scattered six hits in eight innings. Helling (7-5) didn’t allow a run after he gave up Craig Paquette’s opposite-field home run in the first inning and improved to 3-0 in his last four starts.

Padres 5, Mariners 3

San Diego Wiki Gonzalez hit a three-run homer and 20-year-old left-hander Oliver Perez won his major league debut as San Diego beat Seattle.

Jamie Moyer (6-3) allowed five runs four earned and eight hits in 42/3 innings.