Milwaukee Marquette handed Cincinnati its worst loss in five years by beating the Bearcats at their own game.
The Golden Eagles used a tenacious defense and a deliberate, guard-heavy offense to end the nation's longest winning streak at 20 with a 74-60 rout of the fourth-ranked Bearcats on Saturday.
It was Cincinnati's largest margin of defeat since a 97-83 loss to South Carolina on Feb. 15, 1997.
Dwyane Wade (25 points), Cordell Henry (20) and Travis Diener (11) accounted for the bulk of the scoring as Marquette (19-3, 8-1 Conference USA) handed the Bearcats (20-2, 8-1) their first loss since their season opener against Oklahoma State.
The game drew a crowd of 18,698 to the Bradley Center, the largest to watch a college basketball game in Wisconsin. After the Golden Eagles dribbled out the clock, the student section emptied onto the floor and carried off Wade.
"We got beat in every way possible, from me on down," Cincinnati coach Bob Huggins said.
No. 1 Duke 98, Clemson 88
Clemson, S.C. Jason Williams scored 28 points to lead the Blue Devils to their eighth straight victory. Duke (20-1, 8-1 ACC) has won 13 games consecutive games against Clemson. Edward Scott and Tony Stockman each had 20 points for the Tigers (11-11, 2-7), who took a 66-65 lead with 11:23 left and were within 77-76 with 5:24 to play. But Duke scored 10 straight points, four by Mike Dunleavy who finished with 22.
No. 5 Florida 76,
Mississippi State 48
Gainesville, Fla. Matt Bonner had 25 points 20 in the first half and eight rebounds, and Florida (16-4, 5-3 SEC) snapped a three-game losing streak. Florida scored the game's first 10 points and the Gators led by as many as 29 points. Mario Austin had 10 points for the Bulldogs (17-5, 4-4), who set season-lows for points in a half and game.
No. 7 Alabama 57, LSU 48
Baton Rouge, La. Erwin Dudley had 12 points and 16 rebounds to lead the Crimson Tide (19-3, 7-1 SEC) who shot 36 percent from the field, including 12 percent from three-point range (2-of-17) but still handed LSU its fourth straight loss. Ronald Dupree had 19 points and 14 rebounds for LSU (12-9, 2-6), which was 9-of-20 from the foul line.
No. 10 Kentucky 91,
South Carolina 74
Lexington, Ky. Gerald Fitch tied his career-high with 17 points and Tayshaun Prince added 16 for the Wildcats (15-5, 5-3 SEC), who have won six of seven.
No. 11 Gonzaga 94,
Portland, Ore. Dan Dickau scored 39 points to lead Gonzaga (20-3, 7-1 West Coast) over Portland. Casey Frandsen scored 29 points to lead Portland (5-17, 1-7).
No. 13 UCLA 70,
Oregon State 48
Corvallis, Ore. Jason Kapono scored 19 points, and Dan Gadzuric added 18 as UCLA (15-6, 7-4 Pac-10) beat Oregon State, two nights after getting embarrassed at Oregon 91-62. Philip Ricci led Oregon State (10-11, 3-8) with 11 points.
No. 14 Syracuse 74
Piscataway, N.J. Jerome Coleman scored a career-high 27 points, and Rutgers (14-7, 5-4 Big East) posted consecutive wins over ranked teams for the first time in school history. Rutgers beat No. 17 Connecticut on Wednesday. DeShaun Williams and Preston Shumpert each had 21 points for Syracuse (17-6, 6-3), which has lost four of five.
No. 15 Miami 68,
No. 17 Connecticut 66
Miami Elton Tyler made a tie-breaking layup with 13 seconds left and 6-foot-1 Michael Simmons blocked a shot with five seconds remaining for the Hurricanes (19-3, 6-3 Big East). Johnnie Selvie scored 17 points for the Huskies (14-5, 6-2).
No. 16 Georgia 79, Mississippi 72
Athens, Ga. Jarvis Hayes scored 19 points and Steve Thomas added 16 in his return to the starting lineup, as the Bulldogs (17-5, 6-3) ended a two-game losing streak. Thomas was suspended for three games while the school investigated a rape allegation.
No. 19 Arizona 88,
No. 18 Stanford 82, OT
Stanford, Calif. Channing Fyre scored a career-high 22 points and grabbed 10 rebounds and Luke Walton added 20 points for the Wildcats (15-6, 8-3 Pac-10), who improved to 7-3 against ranked opponents. Curtis Borchardt had 25 points and 21 rebounds for Stanford (13-6, 6-4).
No. 21 Pittsburgh 71, Villanova 59
Pittsburgh Julius Page had 18 points for the Panthers (19-4, 7-3 Big East), who pulled away in the second half. Ricky Wright had 10 points and 10 rebounds for the Wildcats (12-7, 4-5), playing the first of four consecutive games against ranked teams.
Oregon 73, No. 23 USC 69
Eugene, Ore. Luke Jackson's three-point play with 38 seconds left gave Oregon the victory and sole possession of first place in the Pac-10. Luke Ridnour added 15 points as Oregon (17-5, 9-2) improved to 13-0 at home. Sam Clancy had 25 points and 11 rebounds for the Trojans (16-5, 8-3).
No. 24 Wake Forest 89, Florida State 80
Tallahassee, Fla. Broderick Hicks scored a career-high 23 points, including eight over the final 77 seconds, and Darius Songaila added 20 for the Deacons (16-6, 6-3 ACC). Monte Cummings had 23 points for Florida State (10-10, 3-6).
No. 25 Ohio State 58, Northwestern 57
Columbus, Ohio Zach Williams hit the second of two foul shots with 16 seconds left for the Buckeyes (17-3, 8-1 Big Ten), and Brent Darby scored a career-high 26 points.