Chicago ? Lorenzo Cain hit two home runs, including a tiebreaking, two-run shot in the ninth inning, as the Kansas City Royals beat the Chicago White Sox, 7-5, on Friday night.

Salvador Perez also hit a two-run homer for the Royals, who won their sixth straight against the White Sox.

Chicago hit three home runs: Alexei Ramirez hit a two-run shot, and Dewayne Wise and A.J. Pierzynski hit solo shots homers.

Kelvin Herrera (2-2) pitched out of a bases-loaded jam in the eighth inning for the Royals.

Johnny Giavotella led off the ninth with a single off Addison Reed (3-2). Cain followed with a deep home run to left center, giving the Royals a 7-5 lead. His seventh home run of the season gave him his first career two-homer game.

Greg Holland pitched the ninth for his 12th save in 14 chances.

The White Sox left the bases loaded in the first and eighth innings. Herrera got Jose Lopez to pop out in the eighth.

With Adam Dunn and Kevin Youkilis missing from the top of the order, the White Sox jumped on starter Luis Mendoza early. Alejandro De Aza led off the first with a single and moved to second on Lopez’s groundout. After Wise walked, Paul Konerko drove in De Aza with a single.

Billy Butler led off the second with a bloop single and Perez extended his hitting streak to 12 games with a two-run home run to left. It was his ninth of the season.

Trailing 2-1, Wise led off the third with a triple, but failed to score. Konerko flied out to shallow right field then Rios followed with another pop fly to shallow right. Giavotella, playing second base, made the catch on Rios’ ball with his back to the plate and Wise tried to tagged from third, but Giavotella made a good throw to the plate to easily get Wise.

Pierzynski tagged Mendoza with a leadoff home run in the fourth to tie the game at 2. It was his 25th of the season.

With two outs in the fifth, Cain teed off on a slider from starter Francisco Liriano to give the Royals a 3-2 lead.

Wise came back with a solo shot in the fifth to tie the game 3-3. It was his seventh of the season.

White Sox manager Robin Ventura pulled Liriano after he issued consecutive walks in the sixth. Jeff Francoeur greeted reliever Nate Jones with an RBI double down the right-field line to put the Royals ahead. Eric Homer gave Kansas City a 5-3 lead with a sacrifice fly.

Liriano has walked 15 batters in his last 14 innings. It was his third straight start that he couldn’t record an out after the fifth inning.

Notes: Dunn (strained right oblique) was out after missing two games due to the same injury. Ventura said he hopes Dunn can return today or Sunday. .. Youkilis left the team to be with his wife, who is expecting to give birth to their first child. Ventura said he hopes Youkilis returns this weekend. … RHP Gavin Floyd (right elbow flexor strain) threw sliders, changeups and fastballs in a 55-pitch bullpen session Thursday. He plans on throwing curveballs in another session.