Columbia, Mo. ? Even without its starting wide receivers, Oklahoma State had plenty left on offense. The Cowboys’ big-play defense stepped up, too.

Joseph Randle scored a career-best four touchdowns, two on runs that capitalized on an interception and fumble recovery by Shaun Lewis, as No. 6 Oklahoma State remained unbeaten and ended Missouri’s 10-game home winning streak with a 45-24 victory on Saturday.

“This place will get kind of rowdy if you let it,” quarterback Brandon Weeden said. “Anytime you get them out of their seats and headed to the exits, that’s huge.”

Missouri quarterback James Franklin committed four turnovers in the second half: three interceptions and a lost fumble at the Oklahoma State 4.

“I know that I didn’t play the best,” Franklin said. “And it’s frustrating. But being sad about it isn’t going to do anything about it.”

Randle had 138 yards on 14 carries and scored on runs of 16, 59 and 12 yards. He also caught a 13-yard touchdown pass in the second quarter.

“He’s a big play waiting to happen,” Weeden said. “The guy is explosive. Without looking at the tape, he’s got to be our MVP.”

Weeden had three touchdown passes after the opening snap of the second quarter. Lewis’ interception and fumble recovery helped the Cowboys (7-0, 4-0 Big 12) pull away and win their ninth in a row on the road despite injuries to both starting wide receivers.

They’re 7-0 for just the third time in school history, also doing it in 2008 and 1945. A major reason: They’ve forced 22 turnovers the last five games.

“They gave us what we had been working on all week,” defensive end Jamie Blatnick said. “When we see what we’ve prepared for it works out for us.”

Justin Blackmon caught a touchdown pass in the first quarter but was held out the second half as a precaution after taking a blow to the head. Hubert Anyiam, the Cowboys’ third-leading receiver, is out for the season with a broken bone in his left foot.

Isaiah Anderson had a career-best five receptions and Tracy Moore matched his career best with seven receptions.

Weeden was 33 for 49 for 338 yards after a sizzling start and extended his streak of 30-yard completions to 15 games. The 28-year-old senior was 19 for 25 for 214 yards in the first quarter, with all six incompletions on drops.

No. 17 Texas A&M 33, Iowa State 17

Ames, Iowa — Ryan Tannehill threw for 263 yards and two touchdowns, and Texas A&M held off Iowa State for its third straight Big 12 win.

Christine Michael and Cyrus Gray each rushed for more than 100 yards for the Aggies (5-2, 3-1 Big 12), who used Tannehill’s scoring passes late in the first half to jump ahead 20-7.

Michael’s nine-yard TD run early in the third quarter gave Texas A&M a 30-7 lead.