Nashville, Tenn. North Carolina made playing at home little advantage for Vanderbilt.
Ivory Latta scored 27 points, and the top-ranked and top-seeded Tar Heels tuned out the pro-Vandy crowd in an 89-70 victory Monday in the second round of the NCAAs.
With the victory, the Tar Heels (31-1) reached the regional semifinals for a second straight year and the 10th in their last 12 tournament appearances. They will play either Purdue or UCLA, who play tonight, on Sunday in Cleveland.
North Carolina advanced in style by winning its first two games on the road for only the second time in school history.
The Tar Heels handed Vanderbilt (21-11) its first NCAA Tournament loss in Memorial Gym, snapping a 15-0 run by the Commodores.