San Francisco ? Reggie Sanders’ two-run double in the eighth spoiled Sidney Ponson’s outstanding debut with the San Francisco Giants and gave the Pittsburgh Pirates a 2-0 victory Wednesday night.

Ponson (0-1), acquired by the NL West leaders in a trade with Baltimore last week, held Pittsburgh scoreless for the first seven innings. He allowed seven hits and retired 10 straight during one stretch, but the Giants couldn’t give him a lead against Pittsburgh starter Josh Fogg, who pitched six shutout innings.

In the eighth, Jason Kendall doubled and Brian Giles walked. Sanders, who played right field for the Giants during last season’s run to the NL pennant, hit Ponson’s 109th pitch over Barry Bonds’ head in left, scoring both runners and snapping the Pirates’ 19-inning scoreless streak.

“I’m not going to sit here and lie and say it’s not (great),” Sanders said. “Every time you step in between those lines, you want to do well — but especially against your former team.”

Ponson then tipped his cap to the Pacific Bell Park crowd after he was removed.

The Pirates won for just the fourth time in their last 21 games in San Francisco, while the Giants lost at home for just the second time in their last 15.

Marlins 7, Cardinals 3

St. Louis — Rookie Dontrelle Willis pitched eight impressive innings, and Ivan Rodriguez homered as Florida beat St. Louis. Willis (11-2), who beat Randy Johnson in his last outing, shrugged off a shaky start to tie the team record for wins by a rookie set by Brian Meadows in 1998. Willis walked Bo Hart on four pitches to start the game and gave up a two-run double to Scott Rolen later in the first, but was virtually unhittable after that.

Astros 11, Mets 1

San Francisco's Sidney Ponson delivers a pitch to the Pittsburgh Pirates during the Giants' 2-0 loss. Ponson was making his Giants debut Wednesday in San Francisco.

Houston — Adam Everett hit the first inside-the-park home run at Minute Maid Park, and Jeff Bagwell and Richard Hidalgo each homered and drove in three runs for Houston. Wade Miller (8-10) allowed one run and six hits in six innings.

Braves 10, Brewers 2

Milwaukee — Greg Maddux won his fifth straight game, and Marcus Giles and Andruw Jones each hit a pair of home runs as Atlanta beat Milwaukee.

Rockies 5, Phillies 1

Denver — Chin-hui Tsao allowed two hits in six innings, and Todd Helton hit a three-run homer in Colorado’s victory over Philadelphia. Tsao (2-0), the first Taiwanese pitcher in the major leagues, combined with three relievers on a five-hitter.

D’backs 3, Expos 2

Phoenix — Carlos Baerga’s tiebreaking pinch-hit single in the eighth inning led Arizona past Montreal.

Dodgers 2, Reds 1

Los Angeles — Odalis Perez took a no-hit bid into the sixth inning, and Adrian Beltre hit a tiebreaking RBI single in the seventh as Los Angeles beat Cincinnati.

Cubs 3, Padres 2

San Diego — Kerry Wood struck out 10, and Sammy Sosa hit a 448-foot homer as Chicago beat San Diego.