In the same game as they lost wide receiver Darrel Jackson to a concussion, the Seattle Seahawks lost quarterback Trent Dilfer for the season when he tore his right Achilles' tendon in the second quarter.
Seattle coach Mike Holmgren said Dilfer will have surgery today in Seattle.
"I feel so bad for him. It's been an unlucky year for him," Holmgren said. "It looked like he got hurt when he was out scrambling."
Dilfer took an awkward step as he dropped back to pass. He still was able to roll out to his right to avoid defenders and complete the pass to Shaun Alexander for 8 yards.
He was replaced by Matt Hasselbeck, who will start the rest of the season.
In the New Orleans Saints' game against the Atlanta Falcons, Saints defensive tackle Grady Jackson sprained his right knee and Falcons cornerback Juran Bolden also sprained his right knee.
Tampa Bay defensive end Anthony McFarland broke his right wrist in Sunday's 12-9 win over Carolina.
McFarland, a first-round draft pick in 1999, was injured when he collided with Carolina quarterback Randy Fasani.
"We don't know the full severity of that, but obviously we are very concerned," Tampa Bay coach Jon Gruden said.
Bucs receiver Joe Jurevicius also left with a sprained right knee and ankle.
Panthers linebacker Dan Morgan left with a groin injury but returned in the third quarter.
Lions OT Stockar McDougle had a groin injury and Desmond Howard injured a rib in Detroit's 24-17 loss to Buffalo.
Titans CB Dainon Sidney broke his left forearm and Bengals CB Jeff Burris pulled his right hamstring in the Titans' 30-24 win.
Jets right tackle Kareem McKenzie sprained his right ankle in the Browns' 24-21 victory.
The Cardinals lost backup wide receiver Bryan Gilmore on an end-zone collision late in the first half of their 38-28 loss to the 49ers. Gilmore's leg was placed in a clear protective boot, and he was taken to the locker room on a cart. Also, 49ers running back Garrison Hearst (hamstring) and linebacker Jeff Ulbrich (hyperextended knee) missed most of the second half.