Kirk Hinrich went down late in the first half, clutching his ankle, and was taken immediately into the lockers. X-rays returned negative on a break, but probably indicate a severe sprain. He did not return to the game, and is doubtful for Saturday's second-round match.
Holy Cross capitalized on the loss of Hinrich, and opened a lead of up to five points on the number one seed, Kansas. The Crusaders held onto their lead by slowing down the game's pace, draining as much time off the clock as they can on each possession.
Kansas has since regained control of the lead, if not the game, and managed to keep the underdogs to just two points in the game's final two minutes.
When KU jumped out to an early 11-4 lead, they looked to have the game well in hand. The only problem is that they forgot to tell their opponents. Holy Cross promptly went on a 14-4 tear, to build a three-point lead of their own by the 11:25 mark of the first half.
The bleeding ended after two more Holy Cross points, and Kansas regained the lead two minutes later.
KU's lead never stretched beyond a few points, and the Crusaders refused to be put away. Several ties and lead changes later, and the heavily favored Jayhawks went into the lockers trailing by two points.
No number one seed has ever lost to a number 16 in the NCAA men's tournament.
Drew Gooden led all scoring with 19 points, 13 rebounds and five assists. Jeff Boschee had 13 points, Hinrich and Keith Langford each had nine.
Kansas will play the winner of tonight's Stanford-Western Kentucky game.
See tonight's 6News broadcast on Sunflower Broadband Channel 6, tomorrow's Lawrence Journal-World and KUSports.com, for full coverage of tonight's game.