Lorenzo Cain had a two-run double to highlight a five-run first inning, Jeremy Guthrie pitched into the sixth inning and Kansas City extended its winning streak to five games with a 7-2 victory over the Chicago White Sox on Friday night.

Guthrie (3-6) allowed two runs and six hits in 5 2/3 innings to snap an 11-game winless streak. Guthrie’s last win was on April 9, against Tampa Bay.

Eric Hosmer and Billy Butler of the White Sox each had two RBIs, including a run-scoring single in the first inning.

Jose Quintana (3-7) never recovered from the slow start, allowing six runs and eight hits in six innings.

Jose Abreu went 1 for 4 with an RBI for the White Sox.

The Royals staked Guthrie to a five-run lead before he took the mound.

The first four batters — Nori Aoki, Omar Infante, Hosmer and Butler — all singled to make it 2-0 and fifth-place hitter Alex Gordon followed with a double to right field to make it 3-0.

After Quintana struck out Salvador Perez for the first out of the game, Cain stroked a double to left to drive in two more and made it 5-0.

The White Sox got a run back in the bottom of the first on a sacrifice fly by Abreu. The Royals got it back in the top of the second on a sacrifice fly by Hosmer.

Chicago loaded the bases with no outs in the bottom half of the inning as Alexei Ramirez and Dayan Viciedo singled and Alejandro De Aza walked, but the White Sox pushed across just one run — on a walk to Adam Eaton — to make it 6-2.

Guthrie struck out Tyler Flowers with no outs and then struck out Gordon Beckham with one out following the walk to Eaton. Conor Gillaspie then flied out to center to end the inning.

The starters then settled down and neither team scored over the next four innings. Kansas City added a run in the seventh on Hosmer’s run-scoring single to make it 7-2.

NOTES: The White Sox have signed RHP Henry Rodriguez to a minor league contract. Rodriguez, released by Miami earlier this season, has been assigned to Triple-A Charlotte and will begin on the DL. . The last time LHP Chris Sale had a high pitch count he landed on the DL for a month, but manager Robin Ventura had no problems with the Chicago ace throwing 116 on Thursday. “He felt great going there and he didn’t have that inning where he really had to fight through it and battle,” Ventura said. . LHP Danny Duffy (3-5) takes on RHP Hector Noesi (2-4) in the second game of the series Saturday.