Topeka ? A deadly storm that halted travel throughout the Great Plains weakened Tuesday as it headed east into Missouri and toward the Great Lakes, and officials reopened interstates in areas where motorists had been forced to adjust holiday plans mid-trip.

A Texas Highway Patrol trooper with the Texas Department of Safety stops traffic on Interstate 40 near Hope Road outside Amarillo Texas Tuesday, Dec. 20, 2011 after a severe winter storm hit Northwest Texas. Travelers in the Texas Panhandle were urged to stay off ice-packed roads Tuesday after up to 10 inches of snow covered parts of the region. Several major thoroughfares were closed after the storm clipped the far northwest part of the state the day before the official start of winter.

Snow sticks to road signs along I-70 near Paxico, Kan., Tuesday, Dec. 20, 2011. A deadly storm that halted travel throughout the Great Plains weakened Tuesday and officials reopened Interstate 40 in the Texas Panhandle and New Mexico, and portions of Interstate 70 in western Kansas that had been closed in both directions.

Authorities still were reporting snow drifts of up to 10 feet high in southeast Colorado, and Texas officials warned drivers to stay off the road in the Panhandle so crews would have a clear path to remove ice and snow. Major highways in the western half of the Oklahoma Panhandle remained closed.

Still, officials reopened Interstate 40 in the Texas Panhandle and New Mexico, and portions of Interstate 70 in western Kansas that had been closed. New Mexico reopened a closed section of Interstate 25, the main highway from Santa Fe to the Colorado line after crews cleared drifts as high as 5 feet. The storm dumped as much as 15 inches of snow as it hit parts of five states.

At least 40 people were stranded at the Longhorn Motel on Main Street in Boise City, Okla., where manager Pedro Segovia said blowing snow had created drifts 2- and 3-feet high and closed the main road.

“Some people cannot even get out of their houses. There is too much snow,” Segovia said. “It’s was blowing. We’ve got big piles. It’s real bad.”

Receptionist MaKenzee Grove sympathized with the 50 or so people stranded at the hotel where she works in Guymon, about 60 miles east of Boise City. She too spent Monday night there.

“I have this rinky-dink car that does not do well in this,” Grove said. “If we wouldn’t have had the wind, it wouldn’t have been as bad. The winds … made the drifts really bad.”

A few guests traveling to Oklahoma City managed to leave Tuesday, but others would likely have to wait another night before all roads were clear, she said.

In Kansas, schools in Manhattan canceled classes Tuesday, anticipating several inches of snow. Topeka was pelted by a cold rain, which was expected to turn to a wintry mix of light sleet and snow later in the day, though forecasters expected the storm to become less potent as it moved northeast toward the Great Lakes.

Kansas Highway Patrol Trooper Ben Gardner said the patrol dealt with dozens of accidents in which motorists slid off highways Tuesday morning.

“We had ice-covered roads, covered by snow packed on top,” he said.

The late-autumn snowstorm lumbered into the region Monday, turning roads to ice and reducing visibility to zero. Many of the areas hit Monday had enjoyed relatively balmy 60-degree temperatures just 24 hours earlier.

The storm was blamed for at least six deaths Monday, authorities said. Four people were killed when their vehicle collided with a pickup truck in part of eastern New Mexico where blizzard-like conditions are rare, and a prison guard and inmate died when a prison van crashed on an icy road in eastern Colorado.

Associated Press writers Jeri Clausing in Albuquerque, N.M.; Matt Curry in Dallas; and Tim Talley in Oklahoma City contributed to this report.