Los Angeles ? “The Other Guys” are the main guys at the box office, knocking off “Inception” to take the No. 1 spot.

The buddy-cop parody starring Will Ferrell and Mark Wahlberg made $35.6 million in its opening weekend, according to Sunday estimates from Sony Pictures.

It’s the second-highest debut for a film in which Ferrell has starred, and yet another strong showing for the movies he’s made with his frequent collaborator, writer-director Adam McKay. Their biggest opening was “Talladega Nights: The Ballad of Ricky Bobby,” which debuted at No. 1 with $47 million in August 2006. “Step Brothers” made $30.9 million and came in second place when it opened in July 2008. And their first film together, “Anchorman: The Legend of Ron Burgundy,” opened in second place in July 2004 with $28.4 million.

Estimated ticket sales for Friday through Sunday at U.S. and Canadian theaters, according to Hollywood .com.

1. “The Other Guys,” $35.6 million.

2. “Inception,” $18.6 million.

3. “Step Up 3-D,” $15.5 million.

4. “Salt,” $11.1 million.

5. “Dinner for Schmucks,” $10.5 million.

6. “Despicable Me,” $9.4 million.

7. “Cats & Dogs: The Revenge of Kitty Galore,” $6.9 million.

8. “Charlie St. Cloud,” $4.7 million.

9. “Toy Story 3,” $3 million.

10.”The Kids Are All Right,” $2.6 million.