Paris ? A sprinkle of rain, like soft tears, fell in the final game on one more day of sadness and frustration for Anastasia Myskina, the first defending French Open champion, male or female, ever to lose in the first round.

The thrill of her shocking victory a year ago seemed a mocking memory for the wispy Russian. Fans who cheered her then now unsympathetically whistled when she smacked her racket on the court in anger at herself. Shots she couldn’t miss last year have been flying wildly most of the time since. She can’t find her footing, her rhythm. Her mind wanders between points and during rallies.

Much of it is understandable. Her thoughts have been with her seriously ill mother, and there are times when the 23-year-old Myskina feels she should not be playing at all. Her dark eyes were sad and downcast Monday during her 6-4, 4-6, 6-0 loss to Spanish 18-year-old Maria Sanchez Lorenzo, in stark contrast to her bright orange tank top and white short shorts on an afternoon when the red clay courts were alternately sun-dappled and rain-speckled. One moment it was warm, the next chilly and blustery.

It was a day that featured a parade of former champions and hot newcomers, a tease of what might be expected over the next two weeks. The top-seeded players, Roger Federer and Lindsay Davenport, advanced, as did the 18-year-old sensations Rafael Nadal of Spain and Richard Gasquet of France.

“I was a little more nervous than usual. I felt maybe a little insecure,” said No. 4 seeded Nadal, winner of five clay-court titles this year.

“My idea was to look at this as one more match, with nothing really special about it.”

Defending men’s champ Gaston Gaudio also won, along with all the other seeded men in action except No. 17 Dominik Hrbaty.

Venus Williams, coming off a victory in a clay tuneup in Turkey and seeking her first French title, won easily, as did Kim Clijsters, a two-time French Open runner-up.

“For sure I want to win this one,” said Williams, who owns two Wimbledon and two U.S. Open titles.

Clijsters showed no sign of her recent knee injury during her 6-1, 6-0 romp over qualifier Meilen Tu, but looked gimpy afterward walking away from Roland Garros. Clijsters, out much of last year because of a wrist injury, hadn’t played a Grand Slam match since January 2004.

“I had to test it out there,” Clijsters said of her heavily wrapped right knee. “This is good to have a match like this in the first round.”

Myskina became only the third woman in the Open era to fall in the first round of a Grand Slam tournament the year after winning. It happened to Steffi Graf at Wimbledon in 1994 and to Jennifer Capriati at the Australian in 2003. It happened four times to men’s defending champions in majors.

“Right now, I know for me it’s difficult really to understand what I have to do on the court,” she said. “When the balls come to me, I don’t really know what I have to do. … I have no confidence at all right now on the courts.”

She didn’t use a sore shoulder as an excuse.

“If my shoulder would be ready for 100 percent, I still would not win this match,” she said.